ADAMTS6
ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6, also written ADAM-TS6) is a secreted metalloproteinase of the ADAMTS family. It is found in the extracellular matrix and is produced as a preproprotein that is processed into the mature enzyme. Browse Assay Genie's current range of ADAMTS6 research reagents below, or read on for the biology behind the target.
ADAMTS6 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family, classed under EC 3.4.24.- as a metalloendopeptidase. Members of the family share several distinct protein modules: a propeptide region, a metalloproteinase domain, a disintegrin-like domain and a thrombospondin type 1 (TS) motif. Individual members differ in the number of C-terminal TS motifs, and some carry unique C-terminal domains. The ADAMTS6 protein is secreted and localises to the extracellular space and extracellular matrix.
The ADAMTS6 gene encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This processing step is typical of the family, in which the propeptide region is removed to yield the active protease. According to the NCBI Gene summary, expression of the ADAMTS6 gene may be regulated by the cytokine TNF-alpha, which links this enzyme to inflammatory signalling contexts.
HGNC places the gene in the group of ADAM metallopeptidases with thrombospondin type 1 motif. Its approved name replaced the earlier description a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6. Researchers studying ADAMTS6 often compare it with other ADAMTS proteases to understand how domain organisation relates to function in the extracellular matrix.
ADAMTS6 is a secreted metalloproteinase located in the extracellular matrix, making it relevant to studies of matrix-associated proteolysis.
Differences in C-terminal TS motif number and unique domains across the family make ADAMTS6 useful for comparative protease studies.
Expression of ADAMTS6 may be regulated by TNF-alpha, so it is a candidate for studies of cytokine-driven gene regulation.
ADAMTS6 is produced as a preproprotein and proteolytically processed to a mature enzyme, a feature relevant to zymogen activation research.
ADAMTS6 is a secreted metalloproteinase of the ADAMTS family, found in the extracellular matrix. It is made as a preproprotein and processed into the mature enzyme. The NCBI summary does not detail specific substrates, so its precise functions remain to be defined from primary literature.
ADAMTS6 is also written ADAM-TS6. The full approved name is ADAM metallopeptidase with thrombospondin type 1 motif 6, and UniProt lists it as A disintegrin and metalloproteinase with thrombospondin motifs 6. An older name was a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6.
The NCBI Gene summary states that expression of the ADAMTS6 gene may be regulated by the cytokine TNF-alpha. No specific disease association is given in the source data, and mouse and rat orthologs are not specified here, so check the datasheet of any product for its validated reactivity.
Other ADAMTS family metalloproteinases that share the propeptide, metalloproteinase, disintegrin-like and thrombospondin motif architecture.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UKP5; product specifications from Assay Genie datasheets.