VSIG2
VSIG2 (V-set and immunoglobulin domain containing 2, also known as CTXL or CTH) is a membrane protein belonging to the V-set and I-set domain groups of immunoglobulin-like proteins. It is predicted to act in lipid metabolic processes. Browse Assay Genie's current range of VSIG2 research reagents below, or read on for the biology behind the target.
VSIG2 is a membrane-associated protein encoded by the VSIG2 gene. Experimental functional annotation is limited. The NCBI Gene summary, provided by the Alliance of Genome Resources, describes VSIG2 as predicted to be involved in lipid metabolic process and predicted to be located in the plasma membrane. These statements are predictions, and the precise molecular mechanism of VSIG2 remains to be established.
The VSIG2 protein is classified by HGNC within the V-set domain containing and I-set domain containing groups, and within the IgCAM CXADR-related subfamily of immunoglobulin-type cell adhesion molecules. This places it alongside other proteins built on immunoglobulin-like folds, a feature it shares with related V-set and immunoglobulin domain-containing proteins such as VSIG4 and VSIG8. The human gene is located at 11q24.2, and the mouse ortholog is Vsig2.
The gene is also known by the aliases CTXL and CTH. Researchers studying VSIG2 should note that the protein name, V-set and immunoglobulin domain-containing protein 2, reflects its domain architecture rather than a characterised physiological role. Because the available annotation is predictive, work on VSIG2 often begins with confirming expression and membrane localisation in the system of interest, before exploring any link to lipid handling or cell surface interactions.
VSIG2 is annotated as a membrane protein and is predicted to localise to the plasma membrane, making it a candidate for cell surface studies.
VSIG2 is predicted to be involved in lipid metabolic process, which provides a starting hypothesis for metabolic investigation.
As a V-set and I-set domain protein in the IgCAM CXADR-related subfamily, VSIG2 is relevant to comparative studies of Ig-domain proteins.
With limited experimental annotation, VSIG2 offers opportunities to define expression, localisation and function, including comparison with mouse Vsig2.
The function of VSIG2 is not well characterised experimentally. The NCBI Gene summary states that it is predicted to be involved in lipid metabolic process and predicted to be located in the plasma membrane. UniProt lists it as a membrane protein.
VSIG2 stands for V-set and immunoglobulin domain containing 2. It is also known by the aliases CTXL and CTH. The UniProt entry names the protein V-set and immunoglobulin domain-containing protein 2.
A mouse ortholog, Vsig2, is recorded for the human gene. VSIG2 belongs to the V-set and I-set domain groups and the IgCAM CXADR-related subfamily. Check the datasheet of any product for its validated reactivity.
Other V-set and immunoglobulin domain-containing proteins with research products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96IQ7; product specifications from Assay Genie datasheets.