TSLP
TSLP (thymic stromal lymphopoietin) is a secreted haemopoietic cytokine that acts mainly on myeloid cells and promotes T helper type 2 responses. It is also reported to have antimicrobial activity in the oral cavity and on the skin. Browse Assay Genie's current range of TSLP research reagents below, or read on for the biology behind the target.
TSLP is a haemopoietic cytokine proposed to signal through a heterodimeric receptor complex made up of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells, where it induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells.
The TSLP protein promotes T helper type 2 (TH2) cell responses, which are associated with immunity in several inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. For this reason it is considered a potential therapeutic target for these conditions, and it is a common subject for researchers studying allergic and airway inflammation.
The TSLP gene also has a second, antimicrobial role. The shorter, predominant isoform is an antimicrobial protein with antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis and C. albicans. UniProt notes that it may act as an antimicrobial peptide in the oral cavity and on the skin. Alternative splicing of the gene produces multiple transcript variants. The mouse ortholog is Tslp, which allows comparable studies in murine models.
TSLP promotes TH2 cell responses linked to allergic inflammation, making it a focus for studies of allergic disease mechanisms.
The cytokine is associated with immunity in asthma and chronic obstructive pulmonary disease and is considered a potential therapeutic target.
TSLP enhances maturation of CD11c(+) dendritic cells and drives chemokine release from monocytes, relevant to myeloid cell studies.
The shorter isoform shows antibacterial and antifungal activity, supporting work on host defence in the oral cavity and skin.
TSLP is a haemopoietic cytokine that mainly acts on myeloid cells. It induces release of T cell-attracting chemokines from monocytes, enhances CD11c(+) dendritic cell maturation and promotes TH2 responses. It is proposed to signal through a receptor complex of the TSLP receptor and IL-7R alpha.
Yes. Alternative splicing of the TSLP gene gives multiple transcript variants. The shorter, predominant isoform is an antimicrobial protein with activity against bacteria such as E. coli and S. epidermidis, and against the fungus C. albicans.
TSLP-driven TH2 responses are associated with asthma, allergic inflammation and chronic obstructive pulmonary disease, and it is considered a potential therapeutic target. The mouse ortholog is Tslp; check the datasheet of any product for its validated reactivity.
Receptor partners, TH2 cytokines and other inflammatory mediators studied alongside TSLP.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q969D9; product specifications from Assay Genie datasheets.