Integrin beta 1
Integrin beta 1 (ITGB1, integrin subunit beta 1, also known as CD29, GPIIA and FNRB) is a beta subunit of the integrin family of heterodimeric cell-surface receptors. Integrins mediate cell adhesion and recognition, and this subunit pairs with alpha subunits to form functional receptors. Browse Assay Genie's current range of Integrin beta 1 research reagents below, or read on for the biology behind the target.
Integrin beta 1 is one of the beta subunits that combine with alpha subunits to form heterodimeric integrin receptors. Integrin family members are membrane receptors involved in cell adhesion and recognition across a range of processes, including embryogenesis, haemostasis, tissue repair, immune response and the metastatic spread of tumour cells. At least 18 alpha and 8 beta subunits have been described in mammals, and the ITGB1 gene encodes one of the beta subunits. UniProt also records a role in microbial infection: the protein facilitates rabies infection in a fibronectin-dependent manner and participates in rabies virus traffic after internalisation.
The protein belongs to the integrin beta chain family and is classed by HGNC among both the CD molecules and the integrin beta subunits, which is why it is widely referred to as CD29. UniProt lists a broad subcellular distribution: the cell membrane, focal adhesions, lamellipodia, ruffle and invadopodium membranes, the cleavage furrow, cell junctions, the sarcolemma, recycling endosomes and melanosomes. Multiple alternatively spliced transcript variants of the Integrin beta 1 gene encode different protein isoforms. Orthologues in mouse and rat are both named Itgb1.
The naming history reflects its early characterisation as a fibronectin receptor: the previous HGNC name was integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12). The symbols FNRB, GPIIA, MSK12 and MDF2 all appear as aliases or previous symbols. Researchers studying adhesion, tissue repair or tumour cell dissemination often examine Integrin beta 1 alongside other beta subunits such as ITGB4, ITGB5 and ITGB6.
Integrin beta 1 is a membrane receptor involved in cell adhesion and recognition, making it a core subject for adhesion studies.
Integrin family receptors contribute to embryogenesis and tissue repair, so Integrin beta 1 is relevant to developmental and wound-healing research.
Integrins are implicated in the metastatic diffusion of tumour cells, positioning Integrin beta 1 as a target in cancer cell invasion research.
Integrin beta 1 facilitates fibronectin-dependent rabies infection and participates in viral traffic after internalisation, relevant to host-pathogen studies.
Integrin beta 1 is a beta subunit of heterodimeric integrin receptors, which mediate cell adhesion and recognition in embryogenesis, haemostasis, tissue repair, immune response and tumour cell metastasis. UniProt also notes that it facilitates fibronectin-dependent rabies infection and participates in rabies virus traffic after internalisation.
The gene symbol is ITGB1, and aliases include CD29, GPIIA, FNRB, MSK12 and MDF2. The previous name was integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29). Multiple alternatively spliced transcript variants encode different protein isoforms.
Mouse and rat each have an orthologue named Itgb1. The integrin family is found throughout mammals, with at least 18 alpha and 8 beta subunits described. Check the datasheet of any product for its validated reactivity.
Other integrin beta subunits that share the integrin beta chain family with Integrin beta 1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P05556; product specifications from Assay Genie datasheets.