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FAT3
FAT3 (FAT atypical cadherin 3, also known as protocadherin Fat 3, KIAA1989, CDHF15 and CDHR10) is a membrane protein of the cadherin-related group. It may contribute to interactions between neurites from specific subsets of neurons during development. Browse Assay Genie's current range of FAT3 research reagents below, or read on for the biology behind the target.
FAT3 is a membrane protein that may play a role in the interactions between neurites derived from specific subsets of neurons during development. Beyond this, the functional annotation is limited, and much of what is known about the FAT3 protein is predicted rather than experimentally established.
Predicted functions of FAT3 include calcium ion binding and cell-cell adhesion mediated by cadherin. It is predicted to act upstream of or within several processes, including negative regulation of dendrite development, neuron migration and retina layer formation. It is predicted to be located in dendrites and at the membrane, and to be active in adherens junctions and the plasma membrane.
The FAT3 gene is classified by HGNC as FAT atypical cadherin 3 within the cadherin related gene group. Its previous name was FAT tumour suppressor homolog 3 (Drosophila), and it has also been listed as KIAA1989, CDHF15 and CDHR10. The mouse and rat orthologs are both named Fat3, which allows the protein to be studied in common rodent models of neural development.
FAT3 may mediate interactions between neurites from specific neuronal subsets during development, making it relevant to studies of how neural circuits form.
FAT3 is predicted to act in negative regulation of dendrite development and to be located in dendrites.
FAT3 is predicted to act upstream of or within neuron migration, a process central to neural patterning.
FAT3 is predicted to contribute to retina layer formation and to cadherin-mediated cell-cell adhesion at adherens junctions.
FAT3 may play a role in the interactions between neurites derived from specific subsets of neurons during development. It is also predicted to bind calcium ions, take part in cadherin-mediated cell-cell adhesion, and act in neuron migration, dendrite regulation and retina layer formation.
FAT3 is the HGNC symbol for FAT atypical cadherin 3. UniProt names the protein protocadherin Fat 3. Other aliases are KIAA1989, CDHF15 and CDHR10, and a previous name was FAT tumour suppressor homolog 3 (Drosophila). Check the datasheet of any product for its validated reactivity.
Yes. Orthologs named Fat3 are recorded for both mouse and rat, so the protein can be examined in rodent models. In human, FAT3 belongs to the cadherin related gene group and was originally named as a homolog of the Drosophila FAT tumour suppressor.
Other cadherin-related proteins, adhesion molecules and neurodevelopment markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TDW7; product specifications from Assay Genie datasheets.
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