POU3F3
POU3F3 (POU class 3 homeobox 3, also known as BRN1 or OTF8) is a nuclear POU-domain transcription factor that recognises an octamer sequence in the DNA of target genes. It is linked to the development of the nervous system. Browse Assay Genie's current range of POU3F3 research reagents below, or read on for the biology behind the target.
POU3F3 is a transcription factor that binds DNA and regulates the expression of target genes. The encoded protein recognises an octamer sequence in target gene DNA. UniProt reports that it acts synergistically with SOX11 and SOX4, and that it plays a role in neuronal development. It is also implicated in enhancer activity at the embryonic met-mesencephalic junction, where the enhancer element contains the octamer motif 5'-ATTTGCAT-3'.
The POU3F3 gene encodes a POU-domain containing protein that localises to the nucleus. It belongs to the POU transcription factor family and to the class-3 subfamily. HGNC places it in the group of POU class homeoboxes and pseudogenes. RefSeq summarises the protein as one that may play a role in development of the nervous system. Mouse and rat both carry an ortholog named Pou3f3, which allows the gene to be studied in common rodent models of development.
The protein has also been described as BRN1 and OTF8, and the earlier HGNC name was POU domain class 3, transcription factor 3. Researchers who work on POU3F3 often study it alongside other class-3 POU factors, such as POU3F1, POU3F2 and POU3F4, and alongside its SOX partners. Typical questions concern DNA binding at octamer motifs, cooperation with SOX proteins and gene regulation during neural development.
POU3F3 plays a role in neuronal development, so it is a useful target for studying how transcription factors shape the developing nervous system.
As a POU-domain protein that recognises an octamer sequence in target gene DNA, POU3F3 is relevant to work on sequence-specific transcriptional control.
POU3F3 acts synergistically with SOX11 and SOX4, which makes it a focus for research into cooperative transcription factor activity.
POU3F3 is implicated in enhancer activity at the embryonic met-mesencephalic junction, an element that contains the octamer motif ATTTGCAT.
POU3F3 is a transcription factor that recognises an octamer sequence in the DNA of target genes. It acts synergistically with SOX11 and SOX4, plays a role in neuronal development, and is implicated in enhancer activity at the embryonic met-mesencephalic junction.
POU3F3 is also known as BRN1 and OTF8. Its full HGNC name is POU class 3 homeobox 3, and UniProt lists the protein as POU domain, class 3, transcription factor 3. An earlier HGNC name was POU domain class 3, transcription factor 3.
Yes. Mouse and rat each have an ortholog named Pou3f3. The human protein belongs to the class-3 subfamily of the POU transcription factor family. Check the datasheet of any product for its validated reactivity.
Other POU family transcription factors, including class-3 subfamily members and class-2 POU factors, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P20264; product specifications from Assay Genie datasheets.