HSPB6
HSPB6 (heat shock protein family B (small) member 6, also known as Hsp20 and PPP1R91) is a small heat shock protein that acts as a molecular chaperone. It also contributes to the regulation of smooth muscle relaxation and cardiac myocyte contractility. Browse Assay Genie's current range of HSPB6 research reagents below, or read on for the biology behind the target.
HSPB6 is a small heat shock protein that functions as a molecular chaperone, probably maintaining denatured proteins in a folding-competent state. UniProt annotation describes versatile roles in several biological processes. In muscle, HSPB6 helps regulate smooth muscle vasorelaxation and cardiac myocyte contractility. It may also regulate myocardial angiogenesis, implicating KDR, and overexpression has been reported to mediate cardioprotection and angiogenesis after induced damage.
HSPB6 also stabilises monomeric YWHAZ, thereby supporting the chaperone-like activity of YWHAZ. The protein is found in the cytoplasm and nucleus, and it is also annotated as secreted. It belongs to the small heat shock protein (HSP20) family. The HSPB6 gene is the subject of NCBI Gene and HGNC records, and the RefSeq summary notes that the encoded protein likely plays a role in smooth muscle relaxation. Researchers working with the HSPB6 protein or the HSPB6 gene often study it alongside other small heat shock proteins in muscle and cardiovascular biology.
HGNC classifies the gene within the small heat shock proteins and the protein phosphatase 1 regulatory subunits groups. Its aliases include Hsp20, FLJ32389 and PPP1R91, and its previous name was heat shock protein, alpha-crystallin-related, B6. Mouse and rat each have an orthologous Hspb6 gene, which allows the biology of HSPB6 to be examined in common model organisms.
HSPB6 is annotated as playing a role in smooth muscle vasorelaxation, making it a target for studies of vascular tone and muscle function.
HSPB6 helps regulate cardiac myocyte contractility, and its overexpression is linked to cardioprotection after induced damage.
HSPB6 may regulate myocardial angiogenesis, implicating KDR, which makes it relevant to studies of vessel growth in heart tissue.
As a small heat shock chaperone that stabilises monomeric YWHAZ, HSPB6 is used to explore protein quality control and folding competence.
HSPB6 is a small heat shock protein that acts as a molecular chaperone, probably keeping denatured proteins in a folding-competent state. It helps regulate smooth muscle vasorelaxation and cardiac myocyte contractility, may regulate myocardial angiogenesis, and stabilises monomeric YWHAZ to support its chaperone-like activity.
HSPB6 is the HGNC symbol for heat shock protein family B (small) member 6. It is also called Hsp20, PPP1R91 and FLJ32389, and was previously named heat shock protein, alpha-crystallin-related, B6. UniProt lists the protein as heat shock protein beta-6.
Yes. Both mouse and rat have an ortholog named Hspb6, so the protein can be studied in standard rodent models. HSPB6 belongs to the small heat shock protein (HSP20) family; check the datasheet of any product for its validated reactivity.
Other small heat shock proteins and related chaperone targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O14558; product specifications from Assay Genie datasheets.