SERPINB12
SERPINB12 (serpin family B member 12, also named serpin B12) is a member of the ov-serpin subfamily of serine protease inhibitors. It inhibits trypsin and plasmin and may contribute to cell differentiation. Browse Assay Genie's current range of SERPINB12 research reagents below, or read on for the biology behind the target.
SERPINB12 is a serine protease inhibitor. According to UniProt, it inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa or urokinase-type plasminogen activator. This selectivity distinguishes it from serpins that act on coagulation proteases. The same annotation notes that it may play a role in cell differentiation. NCBI Gene describes the gene as enabling serine-type endopeptidase inhibitor activity.
The protein belongs to the serpin family and the ov-serpin subfamily, named after ovalbumin. UniProt lists its subcellular location as the cytoplasm, while NCBI Gene, drawing on Alliance of Genome Resources data, reports it as located in the extracellular matrix. The SERPINB12 gene is classed by HGNC in the group of serpin peptidase inhibitors. The mouse ortholog is Serpinb12.
NCBI Gene predicts that SERPINB12 is involved in negative regulation of protein catabolic process and acts upstream of or within haematopoietic progenitor cell differentiation. These are predictions, but they fit with the proposed role in differentiation. Earlier HGNC names for the gene were serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12, and serpin peptidase inhibitor, clade B (ovalbumin), member 12. Researchers working on the SERPINB12 protein or gene will find these older names in earlier literature.
SERPINB12 inhibits trypsin and plasmin but not thrombin, factor Xa or urokinase-type plasminogen activator, making it a useful case for studying serpin target selectivity.
As an ov-serpin, SERPINB12 is studied alongside other clade B serpins to understand how family members differ in protease specificity.
UniProt notes a possible role for SERPINB12 in cell differentiation, and NCBI Gene predicts involvement in haematopoietic progenitor cell differentiation.
SERPINB12 is predicted to negatively regulate protein catabolic process, linking it to the control of proteolysis.
SERPINB12 is a serine protease inhibitor. UniProt reports that it inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa or urokinase-type plasminogen activator. It may also play a role in cell differentiation. NCBI Gene lists serine-type endopeptidase inhibitor activity for the gene.
The UniProt entry calls the protein serpin B12, and HGNC uses serpin family B member 12. Earlier HGNC names were serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12, and serpin peptidase inhibitor, clade B (ovalbumin), member 12. No alternative gene symbols are listed.
A mouse ortholog, Serpinb12, is recorded for the human gene. The protein belongs to the serpin family and the ov-serpin subfamily. Check the datasheet of any product for its validated reactivity before using it in a given species.
Other clade B serpins and ov-serpin protease inhibitors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96P63; product specifications from Assay Genie datasheets.