LRRC3C
LRRC3C (leucine rich repeat containing 3C) is a membrane protein of the LRRC3 family. It is predicted to act as a signalling receptor and has been implicated in allergic asthma, though its function remains largely uncharacterised. Browse Assay Genie's current range of LRRC3C research reagents below, or read on for the biology behind the target.
LRRC3C is a leucine-rich repeat-containing protein that belongs to the LRRC3 family. No curated functional annotation is currently available from UniProt, so its biochemical role is inferred rather than established. The NCBI Gene summary, which draws on the Alliance of Genome Resources, describes the protein as predicted to enable signalling receptor activity. It is also predicted to be located in the membrane and to be active in the plasma membrane, consistent with the membrane localisation recorded in UniProt.
The human LRRC3C gene encodes a protein listed in UniProt as Leucine-rich repeat-containing protein 3C. The HGNC approved name is leucine rich repeat containing 3C. No alternative symbols or previous names are recorded for this gene, so LRRC3C is the name used in the literature and in databases. Researchers working on the LRRC3C protein should be aware that most functional statements about it are predictions, and that experimental work is needed to confirm receptor activity, ligands and signalling partners.
In terms of disease relevance, LRRC3C is implicated in allergic asthma according to the NCBI Gene summary. The source data do not specify the mechanism, the cell types involved or the tissues in which the protein is expressed. This makes LRRC3C a candidate for exploratory studies of membrane proteins in allergic airway disease, as well as for comparative work across leucine-rich repeat proteins, where family members often differ markedly in function and localisation.
LRRC3C is implicated in allergic asthma, making it a candidate for studies of the molecular basis of allergic airway disease.
LRRC3C is predicted to have signalling receptor activity and to act at the plasma membrane, so it is of interest for receptor characterisation.
As a member of the LRRC3 family, LRRC3C supports comparative studies of leucine-rich repeat proteins and their diverse roles.
With little curated functional annotation, LRRC3C is a subject for work that tests predicted localisation and activity experimentally.
The function of LRRC3C is not yet fully defined. The NCBI Gene summary says it is predicted to enable signalling receptor activity and to be active in the plasma membrane. It is also implicated in allergic asthma. UniProt currently provides no curated function annotation.
No aliases or previous symbols are recorded for this gene. The HGNC approved name is leucine rich repeat containing 3C, and UniProt lists the protein as Leucine-rich repeat-containing protein 3C. It belongs to the LRRC3 family of leucine-rich repeat proteins.
According to the NCBI Gene summary, LRRC3C is implicated in allergic asthma. The source data give no further detail on mechanism or tissue expression. Check the datasheet of any product for its validated reactivity before planning experiments in a particular species.
Other leucine-rich repeat-containing proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt A6NJW4; product specifications from Assay Genie datasheets.