Lactate
Lactate is the metabolite handled by L-lactate dehydrogenase A-like 6B, encoded by the LDHAL6B gene and also known as LDHL, LDH6B or LDHAL6. The enzyme catalyses the interconversion of L-lactate and pyruvate using NAD(+) as a coenzyme. Browse Assay Genie's current range of Lactate research reagents below, or read on for the biology behind the target.
Lactate is the product and substrate of a reversible reaction in which L-lactate and pyruvate are interconverted, with nicotinamide adenine dinucleotide, NAD(+), acting as the coenzyme. On this page the target is the enzyme L-lactate dehydrogenase A-like 6B, which UniProt annotates as catalysing this interconversion. The NCBI Gene summary describes it as predicted to enable L-lactate dehydrogenase (NAD+) activity and as involved in the lactate metabolic process.
The LDHAL6B gene encodes the protein, which belongs to the LDH/MDH superfamily and to the L-lactate dehydrogenase family in the HGNC gene grouping. According to NCBI Gene, the protein is located in the cytoplasm. A dedicated subcellular location is not annotated in UniProt, and tissue expression is not described in the sources used here, so any LDHAL6B gene or lactate dehydrogenase study should confirm localisation and expression in the system under investigation.
The official HGNC name is lactate dehydrogenase A like 6B. The previous name was lactate dehydrogenase A-like 6, and the gene has also appeared under the symbols LDHL, LDH6B and LDHAL6. Researchers measuring lactate, pyruvate or NAD(+)-dependent dehydrogenase activity will find the nomenclature varies between publications, so searching by several aliases is sensible.
The enzyme is involved in the lactate metabolic process and interconverts L-lactate and pyruvate, placing it within core carbon metabolism studies.
It is annotated as an NAD(+)-dependent L-lactate dehydrogenase, making it relevant to studies of coenzyme-linked oxidation and reduction.
As a member of the LDH/MDH superfamily and LDH family, it supports comparative work across related dehydrogenase genes.
NCBI Gene reports a cytoplasmic location, relevant to investigating lactate and pyruvate conversion within the cell cytosol.
UniProt annotates L-lactate dehydrogenase A-like 6B as catalysing the interconversion of L-lactate and pyruvate, with NAD(+) as the coenzyme. NCBI Gene adds that it is predicted to enable L-lactate dehydrogenase (NAD+) activity and is involved in the lactate metabolic process.
The HGNC name is lactate dehydrogenase A like 6B, and the UniProt name is L-lactate dehydrogenase A-like 6B. Aliases and previous symbols include LDHL, LDH6B and LDHAL6. The previous gene name was lactate dehydrogenase A-like 6. The enzyme carries EC number 1.1.1.27.
The sources supplied do not identify mouse or rat orthologs, so none is stated here. What is documented is its membership of the LDH/MDH superfamily and the LDH family. Check the datasheet of any product for its validated reactivity.
Other lactate dehydrogenase family members and related metabolites that may be of interest in lactate and pyruvate metabolism.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BYZ2; product specifications from Assay Genie datasheets.