SCUBE1
SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1) is a cell surface glycoprotein of the SCUBE family that is expressed in platelets and endothelial cells. It may act as an adhesive molecule and is thought to contribute to vascular biology. Browse Assay Genie's current range of SCUBE1 research reagents below, or read on for the biology behind the target.
SCUBE1 could function as an adhesive molecule. According to UniProt, its matrix-bound and soluble fragments may play a critical role in vascular biology. The protein is found both as a secreted form and at the cell membrane, which fits with a role at the interface between cells and the surrounding matrix, and with the existence of soluble fragments.
The SCUBE1 gene encodes a cell surface glycoprotein that belongs to the SCUBE (signal peptide, CUB domain, EGF-like protein) family. Members of this family share an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. NCBI Gene reports that the protein is expressed in platelets and endothelial cells, two cell types central to the vasculature, and that it may play an important role in vascular biology. The mouse ortholog is Scube1, which allows the biology of this protein to be studied in murine systems.
The approved HGNC name is signal peptide, CUB domain and EGF like domain containing 1, and the previous name was signal peptide, CUB domain, EGF-like 1. Researchers studying the SCUBE1 protein often consider it alongside other SCUBE family members such as SCUBE3, which share the same domain architecture. Work on SCUBE1 centres on its adhesive properties and on how its soluble and matrix-bound fragments relate to vascular function.
SCUBE1 may play an important role in vascular biology, and its matrix-bound and soluble fragments are proposed to contribute to this function.
SCUBE1 is expressed in platelets, making it a relevant protein for studies of platelet biology and the molecules these cells carry.
Expression of SCUBE1 in endothelial cells links it to research on the endothelium and its role in the vessel wall.
SCUBE1 could function as an adhesive molecule, so it is of interest for work on cell surface and matrix interactions.
SCUBE1 could function as an adhesive molecule, and its matrix-bound and soluble fragments may play a critical role in vascular biology. It is a cell surface glycoprotein expressed in platelets and endothelial cells, though its precise functions are still described as putative.
SCUBE1 has the previous name signal peptide, CUB domain, EGF-like 1, and no other aliases are recorded. Like other SCUBE family members, it has an amino-terminal signal peptide, nine EGF-like repeats and a carboxyl-terminal CUB domain.
A mouse ortholog, Scube1, is recorded for this gene, which allows the protein to be studied in murine models. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Other SCUBE family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IWY4; product specifications from Assay Genie datasheets.