MATN2
MATN2 (matrilin 2) is a secreted extracellular matrix protein of the matrilin group and a member of the von Willebrand factor A domain containing protein family. It is involved in matrix assembly and is thought to contribute to filamentous networks in tissue matrices. Browse Assay Genie's current range of MATN2 research reagents below, or read on for the biology behind the target.
MATN2, also called matrilin-2, is a secreted protein annotated in UniProt as involved in matrix assembly. The extracellular matrix is the structural scaffold surrounding cells, and proteins of the von Willebrand factor A domain family, to which MATN2 belongs, are thought to take part in forming filamentous networks within the extracellular matrices of various tissues. In this role, MATN2 is relevant to studies of how matrix components are organised outside the cell.
The MATN2 gene encodes a protein that contains five von Willebrand factor A domains. HGNC places it in the matrilin gene group. The NCBI Gene summary notes that two transcript variants encoding different isoforms have been identified. The mouse ortholog is Matn2, which allows the protein to be studied in murine models.
The NCBI Gene summary states that the specific function of this gene has not yet been determined, so the precise molecular role of the MATN2 protein remains an open research question. Work on MATN2 therefore often centres on defining its contribution to matrix architecture and on distinguishing it from other matrilins and von Willebrand factor A domain proteins. Researchers studying matrix assembly commonly use a MATN2 antibody or MATN2 ELISA kit to follow the secreted protein in experimental systems.
MATN2 is involved in matrix assembly, making it a relevant target for studying how extracellular scaffolds are built and organised.
Von Willebrand factor A domain proteins such as MATN2 are thought to contribute to filamentous networks in the matrices of various tissues.
As a member of the matrilin group, MATN2 can be studied alongside related proteins to define shared and distinct roles.
The specific function of the MATN2 gene is still undetermined, leaving scope for work on its roles and its two reported isoforms.
UniProt annotates MATN2 as involved in matrix assembly. The NCBI Gene summary adds that its protein family is thought to help form filamentous networks in extracellular matrices of various tissues, although the specific function of the gene has not yet been determined.
No aliases or previous symbols are listed in the source data; the protein is named matrilin-2 in UniProt and matrilin 2 by HGNC. The NCBI Gene summary reports two transcript variants that encode different isoforms.
A mouse ortholog, Matn2, is recorded for the human gene, so the protein can be studied in mouse models. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Other matrilins and von Willebrand factor A domain proteins involved in extracellular matrix assembly.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00339; product specifications from Assay Genie datasheets.