KHDRBS1
KHDRBS1 (KH domain-containing, RNA-binding, signal transduction-associated protein 1, also known as Sam68 and p62) is a member of the KHDRBS family of RNA-binding proteins. It has been linked to alternative splicing, cell cycle regulation and RNA 3'-end formation. Browse Assay Genie's current range of KHDRBS1 research reagents below, or read on for the biology behind the target.
KHDRBS1 is an RNA-binding protein that carries a K homology domain and belongs to the KHDRBS family. According to the NCBI Gene summary, the encoded protein appears to have many functions and may be involved in a variety of cellular processes. These include alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis and regulation of human immunodeficiency virus gene expression. This breadth of reported roles makes it a useful subject for researchers studying how RNA processing connects to cell signalling and proliferation.
One specific functional detail comes from UniProt: isoform 3 is expressed only in growth-arrested cells and inhibits S phase. This points to a role for particular KHDRBS1 isoforms in controlling entry into DNA synthesis. The gene undergoes alternative splicing, which produces multiple transcript variants, so studies of the KHDRBS1 gene or KHDRBS1 protein need to consider which variant is under investigation. UniProt lists the protein in the nucleus, the cytoplasm and at the membrane.
The HGNC full name, KH RNA binding domain containing, signal transduction associated 1, reflects the protein's RNA-binding domain and its association with signal transduction. HGNC places the gene in the signal transduction and activation of RNA metabolism family. The protein is also known as Sam68 and p62, and the gene has carried the alias FLJ34027. Orthologous genes named Khdrbs1 are found in mouse and rat, which allows comparative work in rodent systems. Whether a given reagent recognises the human protein, a rodent ortholog or a specific isoform should always be confirmed from its own documentation.
KHDRBS1 may be involved in alternative splicing, making it relevant to studies of how RNA-binding proteins shape transcript variants.
Isoform 3 is expressed only in growth-arrested cells and inhibits S phase, linking KHDRBS1 to control of cell proliferation.
The NCBI Gene summary lists tumorigenesis among the processes KHDRBS1 may be involved in, supporting its study in cancer biology.
KHDRBS1 is implicated in RNA 3'-end formation and in regulation of human immunodeficiency virus gene expression.
KHDRBS1 is an RNA-binding protein that appears to have many functions. It may be involved in alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis and regulation of human immunodeficiency virus gene expression. Isoform 3, found only in growth-arrested cells, inhibits S phase.
KHDRBS1 is also called Sam68 and p62, and FLJ34027 is a further alias. The full HGNC name is KH RNA binding domain containing, signal transduction associated 1. Alternative splicing produces multiple transcript variants, so isoform-specific names may also appear in the literature.
Yes. Mouse and rat both have an ortholog named Khdrbs1, so the protein can be studied in rodent models. The human protein belongs to the KHDRBS family. Check the datasheet of any product for its validated reactivity.
Other KHDRBS family members, RNA-binding and splicing proteins, and cell cycle markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q07666; product specifications from Assay Genie datasheets.