HYAL1
HYAL1 (hyaluronidase 1, also known as LUCA1 or HYAL-1) is a lysosomal hyaluronidase that degrades hyaluronan, a major glycosaminoglycan of the extracellular matrix. It is the major hyaluronidase in plasma and is active at acidic pH. Browse Assay Genie's current range of HYAL1 research reagents below, or read on for the biology behind the target.
HYAL1 is a hyaluronidase that degrades hyaluronan intracellularly. Hyaluronan is one of the major glycosaminoglycans of the extracellular matrix and is thought to be involved in cell proliferation, migration and differentiation. The enzyme is active at an acidic pH, consistent with its lysosomal localisation, and it is also found in the secreted compartment. It is described as the major hyaluronidase in plasma. Researchers studying hyaluronan turnover therefore often turn to the HYAL1 protein as a central point of reference.
The HYAL1 gene encodes a protein of the glycosyl hydrolase 56 family and belongs to the HGNC gene group of hyaluronidases, alongside related family members such as HYAL2, HYAL3 and HYAL4. The gene sits in a cluster of related genes within a region of chromosome 3p21.3 that has been associated with tumour suppression. Multiple transcript variants encoding different isoforms have been reported for the gene. Mouse and rat both carry a Hyal1 ortholog.
HYAL1 was previously named hyaluronoglucosaminidase 1, and LUCA1 is a historical alias. Mutations in the gene are associated with mucopolysaccharidosis type IX, also called hyaluronidase deficiency. UniProt annotation indicates that HYAL1 may have a role in promoting tumour progression and may block TGFB1-enhanced cell growth, though these roles are described cautiously and remain an active area of investigation.
HYAL1 degrades hyaluronan, a major extracellular matrix glycosaminoglycan, making it a key enzyme for studying hyaluronan turnover.
As a lysosomal hydrolase active at acidic pH, HYAL1 is relevant to studies of intracellular glycosaminoglycan degradation.
HYAL1 may promote tumour progression and lies in a chromosome 3p21.3 region associated with tumour suppression.
Mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.
HYAL1 is a lysosomal hyaluronidase that degrades hyaluronan, a major glycosaminoglycan of the extracellular matrix. It is active at acidic pH and is the major hyaluronidase in plasma. UniProt also notes it may promote tumour progression and may block TGFB1-enhanced cell growth.
HYAL1 is also known as LUCA1 and HYAL-1, and its previous HGNC name was hyaluronoglucosaminidase 1. The enzyme is classed as EC 3.2.1.35. Multiple transcript variants encoding different isoforms have been described for the gene.
Mouse and rat both have a Hyal1 ortholog. In humans, mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. Check the datasheet of any product for its validated reactivity.
Other hyaluronidases and the hyaluronan substrate, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q12794; product specifications from Assay Genie datasheets.