SNX13
SNX13 (sorting nexin 13, also known as RGS-PX1 and KIAA0713) is an early endosome membrane protein of the sorting nexin family. It combines a PHOX domain with an RGS domain and acts as a GTPase-activating protein for G alpha(s). Browse Assay Genie's current range of SNX13 research reagents below, or read on for the biology behind the target.
SNX13 is thought to be involved in several stages of intracellular trafficking and may play a role in endosome homeostasis. It is also a GTPase-activating protein (GAP) for G alpha(s). Its RGS domain interacts with G alpha(s), accelerates GTP hydrolysis and attenuates G alpha(s)-mediated signalling. Because it has both trafficking and G protein regulatory roles, SNX13 may link heterotrimeric G protein signalling to vesicular trafficking.
The SNX13 gene encodes a protein that belongs to both the sorting nexin (SNX) family and the regulator of G protein signalling (RGS) family. Its PHOX domain is a phosphoinositide-binding domain, and SNX family members are generally involved in intracellular trafficking. RGS family members are regulatory molecules that act as GAPs for G alpha subunits of heterotrimeric G proteins. UniProt places the SNX13 protein at the early endosome membrane.
Overexpression of SNX13 delays lysosomal degradation of the epidermal growth factor receptor, which points to a role in endosomal sorting of receptors. HGNC lists the gene in the sorting nexins group. The protein is also known as RGS-PX1, a name that reflects its RGS and PX domains, and by the earlier designation KIAA0713. Researchers studying the SNX13 gene or protein will find it relevant where endosomal trafficking and G protein signalling meet. A mouse ortholog, Snx13, is recorded.
SNX13 is a sorting nexin proposed to act at several stages of intracellular trafficking and in endosome homeostasis.
The RGS domain binds G alpha(s), accelerates GTP hydrolysis and attenuates G alpha(s)-mediated signalling.
Overexpression of SNX13 delays lysosomal degradation of the epidermal growth factor receptor, making it relevant to receptor fate studies.
The PHOX domain of SNX13 is a phosphoinositide-binding module, linking membrane lipid recognition to trafficking function.
SNX13 may be involved in several stages of intracellular trafficking and in endosome homeostasis. It also acts as a GAP for G alpha(s), accelerating GTP hydrolysis and attenuating G alpha(s)-mediated signalling, so it may connect G protein signalling with vesicular trafficking.
SNX13 is the HGNC symbol for sorting nexin 13. It is also called RGS-PX1, which reflects its RGS and PX domains, and KIAA0713. UniProt lists the protein as sorting nexin-13, a member of the sorting nexin family.
A mouse ortholog, Snx13, is recorded for the human gene. No rat ortholog is given in the data supplied here. For antibody or ELISA work in other species, check the datasheet of any product for its validated reactivity.
Other sorting nexin family members involved in intracellular trafficking, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y5W8; product specifications from Assay Genie datasheets.