ADM
ADM (adrenomedullin, also known as AM) is a secreted peptide hormone that acts as a potent hypotensive and vasodilatory agent. It is encoded as a preprohormone, Pro-adrenomedullin, and belongs to the adrenomedullin family of neuropeptides. Browse Assay Genie's current range of ADM research reagents below, or read on for the biology behind the target.
ADM is a peptide hormone that acts as a potent hypotensive and vasodilatory agent. It does so by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. ADM also acts as a ligand for the MRGPRX2 receptor in mast cells. Researchers studying vascular tone, neuroendocrine signalling or mast cell biology often work with the ADM protein and measure it with an ADM ELISA kit or detect it with an ADM antibody.
The ADM gene encodes a preprohormone, Pro-adrenomedullin, which is secreted and cleaved to form two biologically active peptides: adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin itself is a 52 amino acid peptide with several functions. These include vasodilation, regulation of hormone secretion and promotion of angiogenesis. It also has antimicrobial activity. The antibacterial effect has been shown to kill E. coli and S. aureus at low concentration.
ADM is classed by HGNC in the neuropeptides gene group and belongs to the adrenomedullin family. The symbol AM is a recognised alias. Mouse and rat both have an orthologous gene, Adm, so the peptide can be studied in common rodent models. The range of reported activities, from cardiovascular control to host defence, makes ADM a useful target across physiology and disease research.
ADM is a potent hypotensive and vasodilatory peptide, making it central to studies of vascular tone and blood pressure regulation.
ADM inhibits catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells, and also regulates hormone secretion.
Adrenomedullin promotes angiogenesis, so ADM is relevant to work on blood vessel formation and remodelling.
ADM has antibacterial activity and acts as a ligand for MRGPRX2 on mast cells, linking it to host defence.
ADM is a secreted peptide hormone that acts as a potent hypotensive and vasodilatory agent by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. It also regulates hormone secretion, promotes angiogenesis, has antimicrobial activity and acts as a ligand for MRGPRX2 in mast cells.
ADM stands for adrenomedullin, with AM as an alias; UniProt names the precursor Pro-adrenomedullin. The preprohormone is cleaved into two active peptides: adrenomedullin, a 52 amino acid peptide, and proadrenomedullin N-terminal 20 peptide.
Yes. Both mouse and rat carry an orthologous gene named Adm, so the peptide can be studied in rodent models. ADM also belongs to the adrenomedullin family. Check the datasheet of any product for its validated reactivity.
Receptor partners and other neuropeptides related to ADM biology with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P35318; product specifications from Assay Genie datasheets.