PNLIPRP1
PNLIPRP1 (pancreatic lipase related protein 1, also known as PLRP1) is a secreted member of the lipase family within the AB hydrolase superfamily. Despite its name, the protein shows very low or undetectable lipase activity in vitro. Browse Assay Genie's current range of PNLIPRP1 research reagents below, or read on for the biology behind the target.
PNLIPRP1 belongs to the lipase family and the wider AB hydrolase superfamily, yet its UniProt entry is named inactive pancreatic lipase-related protein 1. In vitro, it has very low or undetectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters, and it is unable to hydrolyse milk fat. This distinguishes it from catalytically active relatives and makes it a useful point of comparison when studying how lipase-fold proteins have diverged in function.
The human PNLIPRP1 gene encodes a secreted protein, and the mouse and rat orthologues are both designated Pnliprp1. Researchers working with PNLIPRP1 protein, or measuring it with an antibody or ELISA kit, generally do so in the context of extracellular lipid-related biology, since the protein is predicted to be located in the extracellular region.
Annotation from the Alliance of Genome Resources predicts that PNLIPRP1 can bind calcium ions and may show glycerophospholipid phospholipase A1 and lipoprotein lipase activity. It is also predicted to participate in cholesterol homeostasis, high-density lipoprotein particle remodelling and triglyceride catabolism. These are computational predictions and sit alongside the low in vitro activity reported for the purified protein. PNLIPRP1 has also been described as a biomarker of prostate cancer. The alias PLRP1 is commonly seen in older literature. A related gene in the same family, PNLIPRP2, is a useful comparator.
PNLIPRP1 is a lipase-family member with very low or undetectable lipase activity in vitro, making it a model for functional divergence within the AB hydrolase fold.
Predicted roles in cholesterol homeostasis, HDL particle remodelling and triglyceride catabolism make PNLIPRP1 relevant to studies of extracellular lipid handling.
PNLIPRP1 is described as a biomarker of prostate cancer, supporting its use in studies of disease-associated protein expression.
As a secreted protein predicted to act in the extracellular region, PNLIPRP1 is of interest for studying lipase-like proteins outside the cell.
PNLIPRP1 is a secreted lipase-family protein, but in vitro it has very low or undetectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids and cholesterol esters. Predicted functions include calcium ion binding and roles in cholesterol homeostasis and triglyceride catabolism. Its precise physiological role remains to be established.
The HGNC full name is pancreatic lipase related protein 1, and PLRP1 is a recognised alias. UniProt lists the protein as inactive pancreatic lipase-related protein 1. Use these names together when searching the literature, as older papers often use PLRP1.
Mouse and rat both carry an orthologous gene named Pnliprp1, so rodent models can be used for comparative work; check the datasheet of any product for its validated reactivity. NCBI Gene describes PNLIPRP1 as a biomarker of prostate cancer.
Other pancreatic lipase-related proteins and lipase-family targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P54315; product specifications from Assay Genie datasheets.