WNT10A
WNT10A (Wnt family member 10A, Protein Wnt-10a) is a secreted signalling protein of the Wnt family. It acts as a ligand for frizzled receptors and functions in the canonical Wnt/beta-catenin pathway during ectodermal and epithelial development. Browse Assay Genie's current range of WNT10A research reagents below, or read on for the biology behind the target.
WNT10A is a ligand for members of the frizzled family of seven transmembrane receptors, and it functions in the canonical Wnt/beta-catenin signalling pathway. The protein is secreted and is found in the extracellular space and extracellular matrix. In developmental terms, WNT10A plays a role in normal ectoderm development and is required for normal tooth development.
Beyond the teeth, WNT10A is required for the normal postnatal development and maintenance of tongue papillae and sweat ducts. It is needed for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts, and for normal expression of keratins in tongue papillae. It is also required for normal expression of KRT9 in foot plant epithelium and for normal hair follicle function. The mouse ortholog is Wnt10a.
The WNT10A gene belongs to the WNT gene family, whose members encode structurally related secreted signalling proteins implicated in oncogenesis and in developmental processes such as the regulation of cell fate and patterning during embryogenesis. HGNC lists the previous name as wingless-type MMTV integration site family, member 10A. The gene is strongly expressed in promyelocytic leukaemia and Burkitt's lymphoma cell lines, and it is strongly coexpressed with WNT6 in colorectal cancer cell lines. The two genes are clustered in the chromosome 2q35 region. Overexpression may contribute to carcinogenesis through activation of the WNT-beta-catenin-TCF signalling pathway.
These features make WNT10A a useful subject for studies of epithelial appendage biology and Wnt-driven disease.
WNT10A is a frizzled ligand that acts through the canonical Wnt/beta-catenin pathway, making it a relevant ligand for pathway studies.
WNT10A is required for normal tooth development, so it is a focus for research into dental and ectodermal patterning.
WNT10A supports tongue papillae, sweat ducts, plantar epithelium and hair follicle function, including basal cell proliferation and keratin expression.
WNT10A is strongly expressed in certain leukaemia, lymphoma and colorectal cancer cell lines, and overexpression may drive WNT-beta-catenin-TCF signalling.
WNT10A is a secreted ligand for frizzled receptors that signals through the canonical Wnt/beta-catenin pathway. It is required for normal ectoderm and tooth development, for maintenance of tongue papillae and sweat ducts, for keratin expression in these tissues and for normal hair follicle function.
The HGNC full name is Wnt family member 10A, and UniProt calls the protein Protein Wnt-10a. The previous HGNC name was wingless-type MMTV integration site family, member 10A. No other aliases or previous symbols are listed for the gene.
NCBI Gene reports strong WNT10A expression in promyelocytic leukaemia and Burkitt's lymphoma cell lines, and coexpression with WNT6 in colorectal cancer cell lines. Overexpression may promote carcinogenesis via WNT-beta-catenin-TCF signalling. The mouse ortholog is Wnt10a; check the datasheet of any product for its validated reactivity.
Other Wnt family ligands, including the WNT6 gene neighbour, and related canonical Wnt signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9GZT5; product specifications from Assay Genie datasheets.