CD112R
CD112R, encoded by the PVRIG gene, is a cell surface receptor for NECTIN2 that may act as a coinhibitory receptor on T cells. It is also known as PVR related immunoglobulin domain containing, MGC2463 and C7orf15. Browse Assay Genie's current range of CD112R research reagents below, or read on for the biology behind the target.
CD112R is a cell surface receptor for NECTIN2. It may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals, and following interaction with NECTIN2 it inhibits T-cell proliferation. It also competes with CD226 for NECTIN2 binding, so the balance between these receptors at the cell surface is relevant to how NECTIN2 engagement is interpreted by T cells.
The protein is encoded by the PVRIG gene, and UniProt lists it as transmembrane protein PVRIG, located at the cell membrane. NCBI Gene annotates it with signalling receptor activity and phosphatase binding activity, and with involvement in the negative regulation of the T cell receptor signalling pathway. It is located in the plasma membrane. Researchers working with the CD112R protein or the PVRIG gene typically do so in the context of T-cell regulation and NECTIN2-dependent signalling.
The gene was previously named poliovirus receptor related immunoglobulin domain containing, and it has also appeared under the symbols C7orf15 and MGC2463. CD112R is the alias most often used for the protein. Any CD112R antibody or CD112R ELISA kit should be chosen with these alternative names in mind when searching the literature.
CD112R may suppress T-cell receptor-mediated signals and inhibits T-cell proliferation after NECTIN2 interaction, making it relevant to studies of T-cell regulation.
NCBI Gene links the protein to negative regulation of the T cell receptor signalling pathway and to phosphatase binding activity.
As a cell surface receptor for NECTIN2, CD112R is a subject of ligand-binding and receptor-engagement studies.
CD112R competes with CD226 for NECTIN2 binding, which makes it useful for examining balanced receptor interactions at the T-cell surface.
CD112R is a cell surface receptor for NECTIN2. It may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals, and after interaction with NECTIN2 it inhibits T-cell proliferation. It also competes with CD226 for binding to NECTIN2.
The official HGNC symbol is PVRIG, for PVR related immunoglobulin domain containing. Aliases and previous symbols include MGC2463, C7orf15 and CD112R. The gene was previously named poliovirus receptor related immunoglobulin domain containing. UniProt lists the protein as transmembrane protein PVRIG.
CD112R is located at the cell membrane, specifically the plasma membrane per NCBI Gene. It is involved in negative regulation of the T cell receptor signalling pathway and has phosphatase binding activity. Check the datasheet of any product for its validated reactivity.
NECTIN2, CD226 and other T-cell receptors and ligands connected to CD112R signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6DKI7; product specifications from Assay Genie datasheets.