INA
INA (internexin neuronal intermediate filament protein alpha), also known as alpha-internexin, NF-66 and NEF5, is a class-IV neuronal intermediate filament protein able to self-assemble. It is involved in the morphogenesis of neurons. Browse Assay Genie's current range of INA research reagents below, or read on for the biology behind the target.
INA is a class-IV neuronal intermediate filament that is able to self-assemble. It may form an independent structural network without the involvement of other neurofilaments, or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. It may also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks. The protein is involved in the morphogenesis of neurons.
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium and heavy chains. They make up the axoskeleton and functionally maintain neuronal calibre, and they may also play a role in intracellular transport to axons and dendrites. The INA gene is a member of the intermediate filament family and is classified by HGNC within the type IV intermediate filaments group. The encoded alpha-internexin protein is therefore a useful subject for studies of the neuronal cytoskeleton.
The protein has been listed under several names, including internexin neuronal intermediate filament protein alpha, NF-66 and NEF5. Mouse and rat orthologs are both named Ina, which allows the INA gene and its protein product to be studied in rodent models of neuronal structure.
INA is involved in the morphogenesis of neurons, making it relevant to studies of how neuronal structure is established.
INA can self-assemble and may cooperate with NEFL or PRPH, so it is used to examine how filamentous networks are built.
Neurofilaments comprise the axoskeleton, and INA contributes to the structural network that supports axons.
Neurofilaments maintain neuronal calibre and may take part in intracellular transport to axons and dendrites.
INA is a class-IV neuronal intermediate filament that self-assembles and is involved in neuronal morphogenesis. It may form its own structural network or cooperate with NEFL to form the backbone to which NEFM and NEFH attach. It may also cooperate with PRPH.
INA is also called alpha-internexin, NF-66 and NEF5. The HGNC name is internexin neuronal intermediate filament protein alpha, and an earlier name was internexin neuronal intermediate filament protein, alpha. These names all refer to the same gene and protein.
Yes. Mouse and rat both have an ortholog named Ina. INA belongs to the intermediate filament family, and its type IV neurofilament role is studied in rodent systems. Check the datasheet of any product for its validated reactivity.
Other intermediate filament and neuronal cytoskeleton targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16352; product specifications from Assay Genie datasheets.