MAGEC1
MAGEC1 (MAGE family member C1, also known as MAGE-C1 or CT7) is a member of the melanoma antigen gene family. Its protein product is a tumour-specific antigen that can be recognised by autologous cytolytic T lymphocytes. Browse Assay Genie's current range of MAGEC1 research reagents below, or read on for the biology behind the target.
MAGEC1 belongs to the melanoma antigen gene (MAGE) family, whose proteins are described as tumour-specific antigens. Members of this family can be recognised by autologous cytolytic T lymphocytes, which is the basis for their long-standing interest in tumour immunology. UniProt locates the MAGEC1 protein in the cytoplasm.
The MAGEC1 gene encodes a protein with an unusual architecture. It contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, which makes it about 800 amino acids longer than the other MAGE proteins. The MAGE-homologous region is therefore only one part of the full-length MAGEC1 protein, and the repeat-rich region sets it apart from other family members.
The approved HGNC name is MAGE family member C1, and the previous name was melanoma antigen family C1. The protein is also known as melanoma-associated antigen C1, and the gene appears in the literature under the aliases MAGE-C1, CT7, CT7.1 and MGC39366. MAGEC2 is another member of the MAGE C subgroup. The source annotations used for this page do not describe a specific biochemical function for MAGEC1, so its characterisation here rests on its family membership and its recognition by T lymphocytes.
MAGEC1 is a tumour-specific antigen recognised by autologous cytolytic T lymphocytes, making it a relevant subject for studies of T cell recognition of tumours.
As a member of the melanoma antigen gene family, MAGEC1 is studied alongside other MAGE proteins to compare antigen families.
The repeat-rich sequence preceding the MAGE-homologous region makes MAGEC1 a useful case for comparing structure across the MAGE family.
The CT7 alias reflects MAGEC1's designation as a cancer-testis antigen, a grouping of interest in tumour antigen research.
MAGEC1 is a member of the MAGE family of tumour-specific antigens, which can be recognised by autologous cytolytic T lymphocytes. The source annotations do not assign it a specific biochemical activity. UniProt reports it in the cytoplasm.
MAGEC1 is also called MAGE-C1, CT7, CT7.1 and MGC39366. Its UniProt name is melanoma-associated antigen C1, and the earlier HGNC name was melanoma antigen family C1. The current HGNC name is MAGE family member C1.
MAGEC1 carries many unique short repetitive sequences in front of its MAGE-homologous sequence. This makes it about 800 amino acids longer than the other MAGE proteins. Check the datasheet of any product for its validated reactivity.
Other MAGE family members and tumour antigen targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60732; product specifications from Assay Genie datasheets.