OPCML
OPCML (opioid binding protein/cell adhesion molecule like) is a membrane-associated member of the IgLON family within the immunoglobulin superfamily. It binds opioids in the presence of acidic lipids and is probably involved in cell contact; it is also known as OPCM, OBCAM and IGLON1. Browse Assay Genie's current range of OPCML research reagents below, or read on for the biology behind the target.
OPCML is an opioid-binding cell adhesion molecule. According to UniProt, it binds opioids in the presence of acidic lipids and is probably involved in cell contact. The NCBI Gene summary adds that the protein is localised to the plasma membrane and may have an accessory role in opioid receptor function. Studies of the rat counterpart show that it binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein.
The OPCML gene encodes a member of the IgLON subfamily of the immunoglobulin superfamily, and the HGNC places it in the I-set domain containing and IgLON cell adhesion molecule gene groups. The encoded preprotein is proteolytically processed to generate the mature protein. Alternative splicing gives rise to multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
The gene has orthologs in rat (Opcml) and bovine. Because the encoded protein is highly conserved through evolution, it may have a fundamental role in mammalian systems. The approved name reflects both activities described in the literature: opioid binding and cell adhesion. Aliases found in the literature include OPCM, OBCAM and IGLON1, so it is worth searching under each when reviewing the published work on this protein.
OPCML binds opioids in the presence of acidic lipids and may have an accessory role in opioid receptor function, making it relevant to opioid signalling studies.
As an IgLON family member that is probably involved in cell contact, OPCML is studied in work on membrane-mediated cell-cell interactions.
OPCML belongs to the IgLON subfamily of the immunoglobulin superfamily, allowing comparison with related cell adhesion molecules.
The high conservation of OPCML across species suggests a fundamental role in mammalian systems, supporting comparative work with rat and bovine orthologs.
OPCML binds opioids in the presence of acidic lipids and is probably involved in cell contact, according to UniProt. NCBI Gene notes that it sits in the plasma membrane and may have an accessory role in opioid receptor function.
OPCML is also called OPCM, OBCAM and IGLON1, and its full name is opioid binding protein/cell adhesion molecule like. Alternative splicing produces multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
The OPCML gene has orthologs in rat (Opcml) and bovine, and the protein is highly conserved through evolution. This suggests a fundamental role in mammalian systems. Check the datasheet of any product for its validated reactivity.
Other IgLON family members, cell adhesion molecules and opioid receptor targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14982; product specifications from Assay Genie datasheets.