CRISP2
CRISP2 (cysteine rich secretory protein 2) is a secreted member of the CRISP family. It may regulate the activity of some ion channels and, through them, calcium fluxes during sperm capacitation. It is also known as CRISP-2, CT36, GAPDL5 and TPX1. Browse Assay Genie's current range of CRISP2 research reagents below, or read on for the biology behind the target.
CRISP2 is a secreted protein that may regulate the activity of some ion channels. By doing so it is proposed to influence calcium fluxes during sperm capacitation, the process in which sperm become competent to fertilise. The functional annotation is worded cautiously, so much of the detailed mechanism of the CRISP2 protein remains to be established.
The CRISP2 gene encodes cysteine-rich secretory protein 2 and belongs to the cysteine rich secretory protein family, as defined by HGNC. UniProt likewise places the protein in the CRISP family. Genome annotation predicts that it is located in the extracellular region, which is consistent with its classification as a secreted protein. The mouse ortholog is Crisp2.
The gene has gone by several names. Its previous HGNC name was testis specific protein 1 (probe H4-1 p3-1), and the aliases CRISP-2, CT36, GAPDL5 and TPX1 are still found in the literature and in databases. Researchers searching for CRISP2 may therefore meet any of these terms. Within the same family, CRISP3 is a related target that is useful for comparison when studying CRISP family biology.
CRISP2 may regulate calcium fluxes during sperm capacitation, making it a candidate for studies of how sperm acquire fertilising capacity.
CRISP2 may regulate the activity of some ion channels, so it is relevant to work on channel modulation by secreted proteins.
As a CRISP family member, CRISP2 can be studied alongside related proteins such as CRISP3 to compare family functions.
CRISP2 is a secreted protein predicted to act in the extracellular region, relevant to studies of extracellular signalling and localisation.
According to UniProt, CRISP2 may regulate the activity of some ion channels and thereby regulate calcium fluxes during sperm capacitation. It is a secreted protein, and genome annotation predicts it is located in the extracellular region.
CRISP2 is the HGNC symbol for cysteine rich secretory protein 2. Aliases and earlier symbols include CRISP-2, CT36, GAPDL5 and TPX1. The previous gene name was testis specific protein 1 (probe H4-1 p3-1).
A mouse ortholog, Crisp2, is recorded for the human gene. CRISP2 belongs to the CRISP family, which also includes CRISP3. Check the datasheet of any product for its validated reactivity.
Other members of the CRISP family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P16562; product specifications from Assay Genie datasheets.