ATP6AP2
ATP6AP2, also known as the renin receptor, PRR, RENR or ATP6IP2, is a multifunctional membrane protein. It acts as a cellular receptor for renin and prorenin and is involved in assembling the lysosomal V-type ATPase. Browse Assay Genie's current range of ATP6AP2 research reagents below, or read on for the biology behind the target.
ATP6AP2 is a multifunctional protein that works as a cellular receptor for renin and prorenin. It is also involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and in acidification of the endo-lysosomal system. Through this role in V-ATPase assembly and lysosomal acidification, it regulates protein degradation. It may also control signalling pathways important for proper brain development, synapse morphology and synaptic transmission.
In its receptor role, ATP6AP2 may mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in converting angiotensinogen (AGT) to angiotensin I, it may also contribute to the renin-angiotensin system (RAS).
The ATP6AP2 gene encodes a protein associated with ATPases. Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments and cellular pH homeostasis. Of the three ATPase classes (F, P and V), the V-type enzymes have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The ATP6AP2 protein has been found associated with the transmembrane sector of the V-type ATPases. UniProt places it in the endoplasmic reticulum, lysosome, endosome and autophagosome membranes, as well as clathrin-coated and synaptic vesicle membranes, dendritic spine membranes and axons.
The gene's former names, ATPase, H+ transporting, lysosomal interacting protein 2 and lysosomal accessory protein 2, reflect its link to the V-ATPase. Symbols such as ATP6IP2, ATP6M8-9 and M8-9 are older aliases. The mouse and rat orthologues are both called Atp6ap2.
ATP6AP2 binds renin and prorenin and may raise the catalytic efficiency of renin in converting angiotensinogen to angiotensin I.
The protein is involved in assembling the lysosomal V-type ATPase and is associated with its transmembrane sector.
By supporting acidification of the endo-lysosomal system, ATP6AP2 regulates protein degradation.
ATP6AP2 may control signalling pathways important for brain development, synapse morphology and synaptic transmission.
ATP6AP2 is a multifunctional protein. It serves as a cellular receptor for renin and prorenin, may activate ERK1 and ERK2, and helps assemble the lysosomal V-type ATPase. Through that role it supports endo-lysosomal acidification and regulates protein degradation.
UniProt names the protein renin receptor. Aliases include PRR, (P)RR, RENR, M8-9, APT6M8-9, ATP6M8-9 and ATP6IP2. Earlier HGNC names were ATPase, H+ transporting, lysosomal interacting protein 2 and lysosomal accessory protein 2.
Yes. Mouse and rat each have an orthologous gene named Atp6ap2. Researchers working with rodent models should check the datasheet of any product for its validated reactivity.
Other ATPase subunits, proton and ion pumps, and related transporters with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75787; product specifications from Assay Genie datasheets.