MEIS1
MEIS1 (Meis homeobox 1) is a nuclear homeodomain protein of the TALE/MEIS family that acts as a transcriptional regulator. It is required for haematopoiesis, megakaryocyte lineage development and vascular patterning, and is also known as Homeobox protein Meis1. Browse Assay Genie's current range of MEIS1 research reagents below, or read on for the biology behind the target.
MEIS1 is a transcription factor that works in the nucleus to control gene expression. UniProt describes it as a transcriptional regulator of PAX6, and as a transcriptional activator of PF4 when in complex with PBX1 or PBX2. It is required for haematopoiesis, megakaryocyte lineage development and vascular patterning. It may also act as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukaemias, which makes it relevant to studies of blood cell development and malignancy.
The MEIS1 gene encodes a homeobox protein of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. UniProt places it in the TALE/MEIS homeobox family, and HGNC classifies the gene within the TALE class homeoboxes and pseudogenes. Researchers working with the MEIS1 protein often study it alongside its relative MEIS2 and its PBX and HOX partners. The mouse ortholog is Meis1.
Homeobox genes, best characterised by the HOX genes, play a crucial role in normal development, and several homeoproteins are also involved in neoplasia. The MEIS1 gene belongs to this wider group. Its earlier HGNC names, Meis1 (mouse) homolog and myeloid ecotropic viral integration site 1 homolog (mouse), reflect its identification as a mouse gene homologue. Whether you are planning a MEIS1 antibody or MEIS1 ELISA kit experiment, its nuclear localisation and its roles in transcriptional complexes are useful context for assay design.
MEIS1 is required for haematopoiesis, making it a key factor in studies of blood cell development.
MEIS1 is required for megakaryocyte lineage development and activates PF4 transcription in complex with PBX1 or PBX2.
MEIS1 is required for vascular patterning, so it is relevant to investigations of how vessels are organised during development.
MEIS1 may act as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukaemias.
MEIS1 is a nuclear transcriptional regulator. It regulates PAX6 and, with PBX1 or PBX2, activates PF4 transcription. It is required for haematopoiesis, megakaryocyte lineage development and vascular patterning, and may be a cofactor for HOXA7 and HOXA9 in myeloid leukaemia induction.
The HGNC full name is Meis homeobox 1, and UniProt lists the protein as Homeobox protein Meis1. Earlier HGNC names include Meis1 (mouse) homolog and Meis1, myeloid ecotropic viral integration site 1 homolog (mouse). No alternative gene symbols are recorded.
The mouse ortholog is Meis1, which is reflected in the gene's earlier names as a homolog of the mouse gene. MEIS1 belongs to the TALE/MEIS homeobox family. Check the datasheet of any product for its validated reactivity.
MEIS2, a related homeobox family member, with further targets from the same pathways at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00470; product specifications from Assay Genie datasheets.