FTCD
FTCD (formimidoyltransferase cyclodeaminase) is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a product of histidine degradation, into the folate pool. It also binds vimentin filaments originating from the Golgi apparatus. Browse Assay Genie's current range of FTCD research reagents below, or read on for the biology behind the target.
FTCD is a bifunctional enzyme that links histidine catabolism to folate metabolism. According to the NCBI Gene summary, it channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. The N-terminal section of the protein belongs to the formiminotransferase family.
Beyond its metabolic role, UniProt annotates FTCD as a protein that binds and promotes bundling of vimentin filaments originating from the Golgi. This is consistent with its reported subcellular locations: the cytosol, the Golgi apparatus and the centriole of the centrosome. The human protein is encoded on chromosome 21, and mouse and rat each carry an orthologous Ftcd gene, which allows the protein to be studied in rodent models.
The HGNC gene group for FTCD is carbon-nitrogen lyases, and the previous gene name was formiminotransferase cyclodeaminase. Mutations in the FTCD gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been described, so researchers working with FTCD should consider which transcript or protein form is relevant to their experimental system.
FTCD acts in the histidine degradation pathway, converting the metabolite formiminoglutamate so that its 1-carbon units can enter the folate pool.
By channelling 1-carbon units to the folate pool, FTCD connects amino acid breakdown with folate-dependent metabolism.
FTCD binds and bundles vimentin filaments originating from the Golgi, making it relevant to studies of Golgi-associated cytoskeletal organisation.
Mutations in the FTCD gene are associated with glutamate formiminotransferase deficiency, a focus for genetic and metabolic disease research.
FTCD is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of histidine degradation, to the folate pool. UniProt also records that it binds and promotes bundling of vimentin filaments originating from the Golgi.
The HGNC full name is formimidoyltransferase cyclodeaminase, and the previous name was formiminotransferase cyclodeaminase. UniProt lists the protein as formimidoyltransferase-cyclodeaminase. No alternative gene symbols are listed, and alternatively spliced transcript variants have been found for the FTCD gene.
Mouse and rat both have an orthologous Ftcd gene; check the datasheet of any product for its validated reactivity. In humans, mutations in FTCD are associated with glutamate formiminotransferase deficiency.
Vimentin and other cytoskeletal or metabolic targets related to FTCD biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95954; product specifications from Assay Genie datasheets.