BIN2
BIN2 (bridging integrator 2, also known as BRAP-1) is a member of the N-BAR domain containing gene group. It promotes cell motility and migration, modulates membrane curvature and contributes to podosome formation. Browse Assay Genie's current range of BIN2 research reagents below, or read on for the biology behind the target.
BIN2 acts at the interface between the cell membrane and the cytoskeleton. It modulates membrane curvature and mediates membrane tubulation, and it is thought to promote cell motility and migration through its interaction with the cell membrane and with podosome proteins that link to the cytoskeleton. It also plays a role in podosome formation and inhibits phagocytosis. NCBI Gene annotation adds that the protein enables phospholipid binding and is involved in phagocytosis, engulfment, plasma membrane tubulation and podosome assembly.
The human BIN2 gene encodes bridging integrator 2, a protein of 565 amino acids. According to UniProt, it is found in the cytoplasm, where it associates with the podosome membrane, the cell cortex and the phagocytic cup. Mouse and rat orthologs, both named Bin2, are recorded, which allows comparative work across common model species.
HGNC places BIN2 in the N-BAR domain containing group, and it is related to BIN1, another bridging integrator. The alias BRAP-1 appears in the literature alongside the approved symbol. Researchers studying the BIN2 protein or the BIN2 gene are generally interested in how membrane-shaping proteins coordinate podosome assembly, migration and phagocytic processes.
BIN2 promotes cell motility and migration, making it relevant to studies of how membrane-associated proteins drive cell movement.
BIN2 plays a role in podosome formation and localises to the podosome membrane, linking membrane and cytoskeletal proteins.
BIN2 modulates membrane curvature and mediates membrane tubulation, a useful model for N-BAR domain function.
BIN2 inhibits phagocytosis and is found at the phagocytic cup, supporting work on engulfment mechanisms.
BIN2 promotes cell motility and migration, probably through its interaction with the cell membrane and with podosome proteins that connect to the cytoskeleton. It modulates membrane curvature, mediates membrane tubulation, plays a role in podosome formation and inhibits phagocytosis.
BIN2 stands for bridging integrator 2, and BRAP-1 is a recorded alias. HGNC classifies it in the N-BAR domain containing group. Check the alias when searching older literature, since the approved symbol and the alias may both be used.
Yes. Mouse and rat orthologs, both named Bin2, are recorded for the human gene. This supports comparative studies in rodent models; check the datasheet of any product for its validated reactivity.
Other bridging integrator and N-BAR domain proteins with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UBW5; product specifications from Assay Genie datasheets.