CTRC
CTRC (chymotrypsin C, formerly caldecrin) is a serine protease of the peptidase S1 family that regulates the activation and degradation of trypsinogens and procarboxypeptidases. It is also known by the aliases CLCR and ELA4. Browse Assay Genie's current range of CTRC research reagents below, or read on for the biology behind the target.
CTRC acts on zymogen precursors. According to UniProt, it regulates the activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within these precursors. The protein has chymotrypsin-type protease activity, and it is also annotated with hypocalcaemic activity. This combination places CTRC at the point where proteolytic control of other digestive-type zymogens meets calcium homeostasis.
The CTRC gene encodes a member of the peptidase S1 family, and UniProt places the protein in the elastase subfamily. The HGNC gene group is the chymotrypsins, and the enzyme is classified as EC 3.4.21.2. The NCBI Gene summary describes the encoded protein as a serum calcium-decreasing factor with chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, although their full-length nature has not been determined. Orthologues are annotated in mouse and rat, both named Ctrc, which allows the gene to be studied in standard rodent models.
The naming of this target reflects its history. HGNC lists the previous name as chymotrypsin C (caldecrin), with CLCR and ELA4 recorded as aliases or previous symbols. Researchers may therefore meet the protein under the caldecrin name, the elastase-style symbol ELA4, or the current CTRC symbol. Reagents for the CTRC protein, including a CTRC antibody or CTRC ELISA kit, are used to study these functions in the literature.
CTRC targets specific cleavage sites in trypsinogens and procarboxypeptidases, making it relevant to work on how protease precursors are activated and degraded.
As a chymotrypsin-type member of the peptidase S1 family, CTRC is a subject for studies of protease activity and substrate cleavage.
CTRC is annotated as a serum calcium-decreasing factor with hypocalcaemic activity, which supports investigation of its role in calcium regulation.
Alternatively spliced transcript variants of the CTRC gene have been observed, so their characterisation remains an open question for expression studies.
CTRC is a chymotrypsin-type protease that regulates the activation and degradation of trypsinogens and procarboxypeptidases by cleaving specific sites in their zymogen precursors. It is also annotated with hypocalcaemic activity and described as a serum calcium-decreasing factor.
CTRC stands for chymotrypsin C. HGNC records the previous name as chymotrypsin C (caldecrin) and lists CLCR and ELA4 as aliases or previous symbols. UniProt uses the protein name Chymotrypsin-C. NCBI notes that alternatively spliced transcript variants have been observed.
Yes. Mouse and rat orthologues are both annotated as Ctrc. The human protein belongs to the peptidase S1 family, elastase subfamily, and the HGNC gene group is chymotrypsins. Check the datasheet of any product for its validated reactivity.
Other chymotrypsins, elastases, trypsinogens and procarboxypeptidase-related proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99895; product specifications from Assay Genie datasheets.