TAC3
TAC3 (tachykinin precursor 3, also known as neurokinin beta, neuromedin K, NKB and NK3) is a secreted neuropeptide of the tachykinin family. It acts as the ligand for the neurokinin-3 receptor TACR3 and is a critical central regulator of gonadal function. Browse Assay Genie's current range of TAC3 research reagents below, or read on for the biology behind the target.
TAC3 is a ligand for the G protein-coupled receptor TACR3. Binding to TACR3 triggers signalling through activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C. It also activates adenylate cyclase, which raises intracellular levels of cyclic AMP (cAMP). Through this signalling, TAC3 acts as a critical central regulator of gonadal function.
The TAC3 gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide. This peptide is primarily expressed in the central and peripheral nervous systems, where it functions as a neurotransmitter. TAC3 is also expressed in the outer syncytiotrophoblast of the placenta. Alternative splicing produces multiple transcript variants, and at least one of them encodes an isoform that is proteolytically processed. Mouse and rat both have a Tac3 ortholog.
TAC3 has several historical names, including neuromedin K, neurokinin beta and tachykinin 3, and it is listed by HGNC in the tachykinin precursors gene group. Its disease relevance is reported in two settings. Mutations in the gene are associated with normosmic hypogonadotropic hypogonadism. Placental expression of the protein may be associated with pregnancy-induced hypertension and pre-eclampsia. These links make the TAC3 gene and protein relevant to studies of neuroendocrine signalling and reproductive biology, whether the work uses a TAC3 antibody, a TAC3 ELISA kit or recombinant TAC3 protein.
TAC3 is a critical central regulator of gonadal function, and mutations in the gene are associated with normosmic hypogonadotropic hypogonadism.
As a tachykinin neuropeptide expressed in the central and peripheral nervous systems, TAC3 functions as a neurotransmitter.
TAC3 binding to TACR3 activates G(q), phospholipase C-driven phosphatidylinositol hydrolysis and adenylate cyclase, increasing cAMP.
TAC3 is expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia.
TAC3 is a secreted tachykinin neuropeptide that acts as a ligand for TACR3. Receptor binding activates G(q), phospholipase C and adenylate cyclase signalling, raising cAMP. It functions as a neurotransmitter and is a critical central regulator of gonadal function.
TAC3 is also called neurokinin beta (NKB), neuromedin K, tachykinin 3, NK3, NKNB and ZNEUROK1. Aliases also include LncZBTB39 and LncZBTB39-1:2. Alternative splicing gives multiple transcript variants, and at least one encodes an isoform that is proteolytically processed.
Mutations in TAC3 are associated with normosmic hypogonadotropic hypogonadism, and placental expression may relate to pre-eclampsia and pregnancy-induced hypertension. Mouse and rat both carry a Tac3 ortholog; check the datasheet of any product for its validated reactivity.
The TAC3 receptor TACR3 and other tachykinin receptors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UHF0; product specifications from Assay Genie datasheets.