The tachykinin family of secreted neuropeptides is transcribed by TAC3/Tachykinin-3. The mature peptide, which is mostly found in the central and peripheral nervous systems and serves as a neurotransmitter, is generated by proteolysis of the preproprotein precursor. This protein is the neurokinin-3 receptor ligand. This protein may also be found in the outer syncytiotrophoblast of the placenta and has been linked to pregnancy-induced hypertension and pre-eclampsia. The TAC3 mutation is associated with normosmic hypogonadotropic hypogonadism. At least one of the transcripts generated by alternative splicing comprises a proteolytically processed isoform. Normosmic congenital hypogonadotropic hypogonadism and Hypogonadotropic hypogonadism 10 with or without anosmia are two diseases linked to TAC3. RET signalling and GPCR signalling are two pathways that are related to TAC3. Human Tachykinin-3/TAC3 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human Tachykinin-3/TAC3 Recombinant Protein (RPES0550)
Recombinant Human Tachykinin-3 is produced by our E.coli expression system and the target gene encoding Gln17-Glu121 is expressed with a 6His tag at the N-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
13.9 kDa
AP Mol Mass:
16 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM TrisHCl?pH8.0.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
