C1GALT1
C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1), also known as T-synthase or C1GALT, is a membrane glycosyltransferase that builds the core 1 O-glycan, the T antigen. This structure is the precursor for many extended O-glycans on glycoproteins. Browse Assay Genie's current range of C1GALT1 research reagents below, or read on for the biology behind the target.
C1GALT1 is a glycosyltransferase that generates the common core 1 O-glycan structure, Gal-beta1-3GalNAc-alpha1-Ser/Thr, known as the T antigen. It does so by transferring galactose from UDP-Gal to GalNAc-alpha-1-R, where the acceptor is an N-acetylgalactosamine residue already attached to a serine or threonine of a glycoprotein. Core 1 is a precursor for many extended mucin-type O-glycans found on cell surface and secreted glycoproteins, so the activity of this enzyme sits at an early branch point in O-glycan assembly.
The enzyme is classified as EC 2.4.1.122 and belongs to the glycosyltransferase 31 family, Beta3-Gal-T subfamily. HGNC places the C1GALT1 gene in the group of beta 3-glycosyltransferases. UniProt lists the protein as a membrane protein. Human C1GALT1 has mouse and rat orthologs, both named C1galt1.
UniProt describes C1GALT1 as playing a central role in processes such as angiogenesis, thrombopoiesis and kidney homeostasis development. The NCBI Gene summary adds that studies in mice suggest a key role for the gene in thrombopoiesis and kidney homeostasis. The alias T-synthase reflects the T antigen product of the reaction, and C1GALT1 is a common subject in glycobiology work on O-glycosylation.
C1GALT1 forms the core 1 O-glycan, the precursor for many extended mucin-type O-glycans, making it a central enzyme for studying glycoprotein biosynthesis.
Studies in mice suggest C1GALT1 has a key role in thrombopoiesis, so it is relevant to work on platelet production.
UniProt and RefSeq both link C1GALT1 to kidney homeostasis, supporting research into how O-glycans contribute to renal development and function.
C1GALT1 is annotated as playing a central role in angiogenesis, which makes it of interest for studies of vascular development.
C1GALT1 is a glycosyltransferase that transfers galactose from UDP-Gal to GalNAc-alpha-1-Ser/Thr on glycoproteins. This produces the core 1 O-glycan, or T antigen, which is a precursor for many extended mucin-type O-glycans on cell surface and secreted proteins.
C1GALT1 stands for core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1. Aliases include C1GALT and T-synthase. UniProt uses the protein name glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, and the enzyme is classified as EC 2.4.1.122.
Mouse and rat both have a C1galt1 ortholog. Studies in mice suggest the gene plays a key role in thrombopoiesis and kidney homeostasis, and UniProt also notes roles in angiogenesis. Check the datasheet of any product for its validated reactivity.
Other glycosyltransferases and O-glycosylation pathway enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NS00; product specifications from Assay Genie datasheets.