RAB5C
RAB5C (Ras-related protein Rab-5C, also known as RAB5CL or RABL) is a small GTPase of the Rab family that regulates intracellular membrane trafficking. It acts in early endocytic trafficking and is needed for EEA1 recruitment to early endosomes. Browse Assay Genie's current range of RAB5C research reagents below, or read on for the biology behind the target.
RAB5C is a member of the Rab family of small GTPases, which are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Like other Rabs, it cycles between an inactive GDP-bound form and an active GTP-bound form. The active, GTP-bound state recruits different sets of downstream effectors to membranes, and these effectors are directly responsible for vesicle formation, movement, tethering and fusion.
RAB5C is involved in early endocytic trafficking. It is required for the recruitment of EEA1 to early endosomes, and for the endocytosis of EGF and transferrin and their trafficking through early endosomes. Its subcellular locations include the cell membrane, the early endosome membrane and the melanosome. The protein belongs to the small GTPase superfamily, Rab family, and carries the GTPase activity classified as EC 3.6.5.2.
The RAB5C gene is listed by HGNC in the group of RAB, member RAS oncogene GTPases, and its full gene name is RAB5C, member RAS oncogene family. Earlier aliases include RAB5CL and RABL. NCBI describes Rab proteins as small GTPases of the Ras superfamily that are thought to ensure fidelity in the docking and/or fusion of vesicles with their correct acceptor compartment. A mouse ortholog, Rab5c, is recorded for the gene. Related Rab5 family proteins include RAB5A and RAB5B.
RAB5C is involved in early endocytic trafficking, making it a relevant target for studying how cargo is taken up and sorted at early endosomes.
RAB5C is required for EEA1 recruitment to early endosomes, linking it to studies of early endosome identity and effector recruitment.
RAB5C is required for EGF and transferrin endocytosis and trafficking through early endosomes, supporting work on receptor internalisation.
Rabs cycle between GDP-bound and GTP-bound forms and recruit effectors, so RAB5C is useful for studying GTPase regulation of vesicle formation and fusion.
RAB5C is a small GTPase that regulates membrane trafficking. It is involved in early endocytic trafficking, is required for EEA1 recruitment to early endosomes, and is needed for EGF and transferrin endocytosis and their trafficking through early endosomes.
The HGNC gene name is RAB5C, member RAS oncogene family, and UniProt names the protein Ras-related protein Rab-5C. Aliases and previous symbols include RAB5CL and RABL. The gene belongs to the HGNC group of RAB, member RAS oncogene GTPases.
Like other Rab proteins, RAB5C cycles between an inactive GDP-bound form and an active GTP-bound form. The GTP-bound form recruits downstream effectors to membranes that drive vesicle formation, movement, tethering and fusion. A mouse ortholog, Rab5c, exists; check the datasheet of any product for its validated reactivity.
Other Rab family GTPases, including fellow Rab5 members and Rabs of the endocytic and recycling pathways, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P51148; product specifications from Assay Genie datasheets.