CEACAM7
CEACAM7 (CEA cell adhesion molecule 7, also known as CEA or CGM2) is a cell surface glycoprotein of the carcinoembryonic antigen family within the immunoglobulin superfamily. It is studied mainly for its altered expression in colon and rectal cancer. Browse Assay Genie's current range of CEACAM7 research reagents below, or read on for the biology behind the target.
CEACAM7 is a cell surface glycoprotein and a member of the carcinoembryonic antigen (CEA) family of proteins. It belongs to the immunoglobulin superfamily and, as its name indicates, is classed as a cell adhesion molecule. UniProt reports it at the cell membrane, including the apical cell membrane. No detailed functional annotation is currently recorded for the protein, so its precise molecular role is best described through its family membership and its expression behaviour rather than a defined mechanism.
The CEACAM7 gene sits within a CEA family gene cluster on chromosome 19. HGNC places it in the V-set domain containing group and in the CEA cell adhesion molecule family. Alternative splicing of the gene produces multiple transcript variants, which is worth bearing in mind when designing experiments that target a particular form of the CEACAM7 protein.
The main disease relevance reported for CEACAM7 concerns colorectal tissue. Expression of the gene may be downregulated in colon and rectal cancer, and lower expression levels may be predictive of rectal cancer recurrence. This has made CEACAM7 a candidate marker in studies of colorectal tumour biology. The protein has also been listed under the names CEA and CGM2, and formerly as carcinoembryonic antigen-related cell adhesion molecule 7, so literature searches should include these alternative names. Related CEA family members such as CEACAM1, CEACAM3, CEACAM6 and CEACAM21 are often examined alongside it for context.
CEACAM7 expression may be downregulated in colon and rectal cancer, making it relevant to studies of colorectal tumour biology.
Lower CEACAM7 expression may be predictive of rectal cancer recurrence, supporting its investigation as a prognostic marker.
CEACAM7 is part of a CEA gene cluster on chromosome 19, so it is studied alongside related family members.
As a cell surface glycoprotein found at the apical cell membrane, CEACAM7 is relevant to work on epithelial membrane proteins.
CEACAM7 is a cell surface glycoprotein of the carcinoembryonic antigen family and the immunoglobulin superfamily. UniProt locates it at the cell membrane, including the apical membrane. No detailed functional annotation is recorded, but its expression is linked to colon and rectal cancer in NCBI Gene.
CEACAM7 is also known as CEA and CGM2. Its previous names include carcinoembryonic antigen-related cell adhesion molecule 7. UniProt lists the protein as cell adhesion molecule CEACAM7. Alternative splicing gives multiple transcript variants, so different literature may describe different forms.
NCBI Gene reports that CEACAM7 expression may be downregulated in colon and rectal cancer. Lower expression may also be predictive of rectal cancer recurrence. These observations make it of interest in colorectal cancer research. Mouse and rat orthologs are not given in the data, so check the datasheet of any product for its validated reactivity.
Other CEA family cell adhesion molecules that are often studied alongside CEACAM7 in colorectal and epithelial research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14002; product specifications from Assay Genie datasheets.