MAN1A1
MAN1A1 (mannosidase alpha class 1A member 1) is a class I Golgi alpha-1,2-mannosidase that takes part in the maturation of Asn-linked oligosaccharides. It trims mannose residues from Man(9)GlcNAc(2) glycans on glycoproteins and belongs to glycosyl hydrolase family 47. Browse Assay Genie's current range of MAN1A1 research reagents below, or read on for the biology behind the target.
MAN1A1 is involved in the maturation of Asn-linked oligosaccharides. The enzyme progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). According to the NCBI Gene summary, it catalyses hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides. This trimming step is part of the processing that converts high-mannose N-glycans into the forms needed for later glycan maturation.
The MAN1A1 gene encodes a class I mammalian Golgi 1,2-mannosidase, a type II transmembrane protein that localises to the Golgi apparatus membrane. UniProt names the product mannosyl-oligosaccharide 1,2-alpha-mannosidase IA and assigns it EC 3.2.1.113. It belongs to the glycosyl hydrolase 47 family, and HGNC places it in the alpha class 1 mannosidases gene group. The mouse ortholog is Man1a1, which is relevant when planning comparative work on N-glycan processing.
The approved name, mannosidase alpha class 1A member 1, replaced the earlier form mannosidase, alpha, class 1A, member 1. Researchers studying glycoprotein biosynthesis, Golgi enzymology and N-glycan structure use MAN1A1 antibody, MAN1A1 ELISA kit and MAN1A1 protein reagents to examine how this mannosidase contributes to oligosaccharide maturation.
MAN1A1 trims alpha-1,2-linked mannose from Man(9)GlcNAc(2) to Man(5)GlcNAc(2), making it a key enzyme for studying Asn-linked oligosaccharide maturation.
As a type II transmembrane protein of the Golgi apparatus membrane, MAN1A1 is a useful subject for studies of Golgi-resident glycosidases.
Mannose trimming by MAN1A1 shapes peptide-bound oligosaccharides, so the enzyme is relevant to research on how glycoproteins are modified.
MAN1A1 belongs to glycosyl hydrolase family 47 and the alpha class 1 mannosidases, supporting comparisons with related mannose-processing enzymes.
MAN1A1 is a Golgi alpha-1,2-mannosidase involved in maturing Asn-linked oligosaccharides. It progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to yield Man(5)GlcNAc(2), and is described as removing three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2).
The HGNC full name is mannosidase alpha class 1A member 1, previously written mannosidase, alpha, class 1A, member 1. UniProt calls the protein mannosyl-oligosaccharide 1,2-alpha-mannosidase IA. No alternative gene symbols are recorded, and the enzyme is classified as EC 3.2.1.113.
A mouse ortholog, Man1a1, is recognised. The protein belongs to the conserved glycosyl hydrolase 47 family and is described as a class I mammalian Golgi mannosidase. Check the datasheet of any product for its validated reactivity.
Other mannosidases and mannose-related proteins that sit alongside MAN1A1 in glycan processing and glycobiology research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P33908; product specifications from Assay Genie datasheets.