DSC3
DSC3 (desmocollin 3) is a calcium-dependent glycoprotein of the desmocollin subfamily of the cadherin superfamily. It is a component of desmosome cell-cell junctions, where it supports cellular adhesion, and it is also known by the aliases CDHF3, DSC, DSC1, DSC2 and DSC4. Browse Assay Genie's current range of DSC3 research reagents below, or read on for the biology behind the target.
DSC3 is a component of desmosome cell-cell junctions, which are required for positive regulation of cellular adhesion. The protein is needed for cell-cell adhesion in the epidermis and therefore for the maintenance of dermal cohesion and the dermal barrier function. It is also required for adhesion of the epithelial cell layers that surround the telogen hair club, giving it an important role in telogen hair shaft anchorage. Beyond skin and hair, DSC3 is essential for successful completion of embryo compaction and embryo development.
Desmocollin-3 is a calcium-dependent glycoprotein belonging to the desmocollin subfamily of the cadherin superfamily, within the HGNC group of desmosomal cadherins. Together with the desmogleins, desmocollins are found primarily in epithelial cells, where they form the adhesive proteins of the desmosome and are required for cell adhesion and desmosome formation. UniProt records the protein at the cell membrane, in the desmosome of cell junctions, and in the cytoplasm. The DSC3 gene lies in one of two desmosomal cadherin clusters on chromosome 18, and alternative splicing produces multiple transcript variants. The mouse ortholog is Dsc3.
DSC3 has clear disease relevance. Mutations in the DSC3 gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered a biomarker for some cancers. These links make it a frequent subject in studies of epithelial integrity, skin autoimmunity and tumour biology.
DSC3 is an adhesive component of desmosome junctions and is required for cell adhesion and desmosome formation in epithelial cells.
DSC3 is required for epidermal cell-cell adhesion, dermal cohesion and barrier function, making it relevant to skin integrity studies.
DSC3 can act as an autoantigen in pemphigus diseases, so it is studied in autoimmune blistering disorders.
DSC3 anchors the telogen hair shaft, is essential for embryo compaction, and is considered a biomarker for some cancers.
DSC3 is a component of desmosome cell-cell junctions and promotes cellular adhesion. It is required for adhesion in the epidermis, for dermal cohesion and barrier function, and for anchoring the telogen hair shaft. It is also essential for embryo compaction and embryo development.
DSC3 is the HGNC symbol for desmocollin 3, and UniProt names the protein Desmocollin-3. Aliases and previous symbols include CDHF3, DSC, DSC1, DSC2 and DSC4. Alternative splicing of the gene produces multiple transcript variants.
Mutations in DSC3 cause hypotrichosis and recurrent skin vesicles disorder, and the protein can be an autoantigen in pemphigus diseases. It is also considered a biomarker for some cancers. The mouse ortholog is Dsc3; check the datasheet of any product for its validated reactivity.
Other desmocollins and desmosomal cadherin family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14574; product specifications from Assay Genie datasheets.