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MAGEB4
MAGEB4 (MAGE family member B4, also known as melanoma-associated antigen B4, CT3.6 and MGC33144) is a member of the MAGEB gene family. The MAGEB4 gene is expressed in testis, and the encoded protein is found in the cytoplasm. Browse Assay Genie's current range of MAGEB4 research reagents below, or read on for the biology behind the target.
MAGEB4 is a member of the MAGEB gene family, part of the wider MAGE family. No specific biochemical function for the MAGEB4 protein is described in the sources used for this page. Its subcellular location is the cytoplasm, and the MAGEB4 gene is expressed in testis.
The MAGEB genes share a distinctive organisation: the entire coding sequence of each gene lies in the last exon, and the encoded proteins show 50 to 68% sequence identity to one another. The promoters and first exons of the MAGEB genes vary considerably. This suggests that the family allows the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21, and the MAGEB4 gene sequence ends in the first intron of MAGEB1, another family member.
The protein is catalogued by UniProt as melanoma-associated antigen B4 and by HGNC as MAGE family member B4, with the previous name melanoma antigen family B4. Alternative designations include CT3.6 and MGC33144. A mouse ortholog, Mageb4, is recorded. Researchers studying MAGEB4 often work alongside other MAGEB family members, for example when comparing expression under different transcriptional controls.
MAGEB4 belongs to the MAGEB family, whose members share 50 to 68% sequence identity and are clustered on chromosome Xp22-p21.
The MAGEB4 gene is expressed in testis, making it a relevant target for studies of testis-restricted expression.
Variable promoters and first exons across MAGEB genes suggest one function expressed under different transcriptional controls, a question MAGEB4 can help address.
MAGEB4 ends in the first intron of MAGEB1, so it is useful for examining the organisation of the clustered MAGEB genes.
The sources used here do not describe a specific molecular function for MAGEB4. It is a member of the MAGEB gene family, its protein is located in the cytoplasm, and the gene is expressed in testis. The family may allow one function to be expressed under different transcriptional controls.
MAGEB4 is the HGNC symbol for MAGE family member B4. UniProt names the protein melanoma-associated antigen B4. Other designations are CT3.6 and MGC33144, and the previous gene name was melanoma antigen family B4. Check the datasheet of any product for its validated reactivity.
A mouse ortholog, Mageb4, is recorded for human MAGEB4. Within humans, MAGEB family proteins share 50 to 68% sequence identity with each other. No rat ortholog is listed in the data used here. Check the datasheet of any product for its validated reactivity.
Other MAGEB family members that share the same gene organisation and clustered chromosomal location.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15481; product specifications from Assay Genie datasheets.
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