SEMA3C
SEMA3C (semaphorin 3C) is a secreted glycoprotein of the class 3 semaphorin family of neuronal guidance cues, also known as SemE or SEMAE. It binds plexin family members and regulates developmental processes, including cardiovascular development and axon guidance. Browse Assay Genie's current range of SEMA3C research reagents below, or read on for the biology behind the target.
SEMA3C is a secreted member of the semaphorin family that binds plexin family members and plays an important role in regulating developmental processes. It is required for normal cardiovascular development during embryogenesis. It also functions as an attractant for growing axons, and so contributes to axon growth and axon guidance.
The SEMA3C gene encodes a secreted glycoprotein of the semaphorin class 3 family of neuronal guidance cues. The protein has an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerisation and proteolytic cleavage of the C-terminal propeptide are necessary for function. SEMA3C binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. HGNC places it in the I-set domain containing and semaphorin gene groups. The mouse ortholog is Sema3c.
The previous HGNC name was sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C, and the aliases SemE and SEMAE are still found in the literature. Higher expression of SEMA3C correlates with increased cancer cell invasion and adhesion, and naturally occurring mutations in the gene are associated with Hirschsprung disease. This makes the SEMA3C protein relevant to both developmental biology and cancer research.
SEMA3C acts as an attractant for growing axons and has an important role in axon growth and guidance.
SEMA3C is required for normal cardiovascular development during embryogenesis, making it a target for developmental studies.
Increased SEMA3C expression correlates with greater cancer cell invasion and adhesion.
SEMA3C binds a neuropilin co-receptor and then forms a heterotrimeric complex with a plexin.
SEMA3C binds plexin family members and regulates developmental processes. It is required for normal cardiovascular development during embryogenesis and acts as an attractant for growing axons, contributing to axon growth and guidance. It first binds a neuropilin co-receptor, then forms a heterotrimeric complex with a plexin.
SEMA3C stands for semaphorin 3C, and the protein is listed as Semaphorin-3C. Aliases include SemE and SEMAE. The earlier HGNC name was sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C. Check the datasheet of any product for its validated reactivity.
According to the NCBI Gene summary, higher SEMA3C expression correlates with increased cancer cell invasion and adhesion. Naturally occurring mutations in the gene are associated with Hirschsprung disease. The mouse ortholog, Sema3c, is the corresponding gene in that species.
Other class 3 semaphorins and related semaphorin family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99985; product specifications from Assay Genie datasheets.