IRAK2
IRAK2 (interleukin 1 receptor associated kinase 2) is a member of the IRAK family of putative serine/threonine kinases that associate with the interleukin-1 receptor after stimulation. It links IL-1 receptor engagement to intracellular signalling and NF-kappaB activation. Browse Assay Genie's current range of IRAK2 research reagents below, or read on for the biology behind the target.
IRAK2 binds to the IL-1 type I receptor following IL-1 engagement. This association triggers intracellular signalling cascades that lead to transcriptional up-regulation and mRNA stabilisation. IRAK2 is reported to participate in the IL-1-induced upregulation of NF-kappaB, placing it among the early adaptors that carry the signal from the activated receptor into the cell.
The IRAK2 protein is named as interleukin-1 receptor-associated kinase-like 2 in UniProt. It belongs to the protein kinase superfamily, within the TKL Ser/Thr protein kinase family and the Pelle subfamily. NCBI Gene describes it as one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. The word putative matters here, because the entry is described as a kinase-like member of its family. The IRAK2 gene is classed by HGNC in the interleukin 1 receptor associated kinase family, and orthologues are recognised in mouse and rat, both named Irak2.
For researchers, IRAK2 is a relevant target when studying IL-1 receptor signalling, NF-kappaB induction and the control of gene expression downstream of IL-1. It is best considered alongside the other members of its family, including IRAK1, IRAK3 and IRAK4, which share the same receptor-proximal signalling context. Work on IRAK2 antibody reagents, IRAK2 protein tools or IRAK2 ELISA kit assays typically aims to place this family member within that pathway.
IRAK2 associates with the IL-1 type I receptor after IL-1 engagement, so it is studied to understand how receptor activation starts intracellular signalling.
IRAK2 is reported to participate in IL-1-induced upregulation of NF-kappaB, making it relevant to work on this transcription factor pathway.
IL-1 signalling through IRAK2 leads to mRNA stabilisation as well as transcriptional up-regulation, which is of interest for gene expression studies.
As a Pelle subfamily kinase-like protein, IRAK2 is examined alongside IRAK1, IRAK3 and IRAK4 to define the roles of each family member.
IRAK2 binds to the IL-1 type I receptor after IL-1 engagement. This triggers intracellular signalling cascades that lead to transcriptional up-regulation and mRNA stabilisation. It is also reported to participate in IL-1-induced upregulation of NF-kappaB.
NCBI Gene describes IRAK2 as one of two putative serine/threonine kinases that associate with IL1R on stimulation. UniProt places it in the protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily. UniProt names it interleukin-1 receptor-associated kinase-like 2.
Yes. Mouse and rat both have an orthologous gene named Irak2. Researchers working across species can therefore study the same family member in rodent models, but check the datasheet of any product for its validated reactivity.
Other members of the IRAK family that act in IL-1 receptor signalling, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O43187; product specifications from Assay Genie datasheets.