TBC1D22A may act as a GTPase-activating protein (GAP) for Rab family proteins. Rab GTPases are regulators of membrane trafficking, and GAPs of this kind promote their return to the inactive state. The evidence for this role is limited to a cautious annotation, so researchers should treat the Rab GAP function of TBC1D22A as putative rather than established.

The TBC1D22A gene encodes a protein that belongs to the HGNC group of TBC1 domain family members. Gene Ontology-based annotation from the Alliance of Genome Resources indicates that it enables binding to 14-3-3 family members and that it can homodimerise. It is also predicted to be active in the Golgi apparatus, although UniProt has not annotated a subcellular location for the protein. A mouse ortholog, Tbc1d22a, is recorded, which allows comparative work in that species.

The gene was formerly named chromosome 22 open reading frame 4 (C22orf4), and its earlier approved name was TBC1 domain family, member 22A. Related family members with their own target pages include TBC1D1, TBC1D3 and TBC1D4, which are useful for comparing TBC1 domain proteins. Anyone searching for a TBC1D22A antibody, TBC1D22A ELISA kit or recombinant TBC1D22A protein will find that the literature is still sparse, so confirm the identity and context of any reagent for your own experiments.