ABCC9
ABCC9 (ATP-binding cassette sub-family C member 9, also known as SUR2 or CMD1O) is a membrane protein of the ABC transporter superfamily. It acts as a regulatory subunit of ATP-sensitive potassium (KATP) channels in cardiac, skeletal and smooth muscle. Browse Assay Genie's current range of ABCC9 research reagents below, or read on for the biology behind the target.
ABCC9 is a subunit of ATP-sensitive potassium channels (KATP). It can combine with KCNJ11 to form cardiac and smooth muscle-type KATP channels. In this pairing KCNJ11 forms the channel pore, while ABCC9 is required for activation and regulation. ABCC9 can also form a sulfonylurea-sensitive but ATP-insensitive potassium channel with KCNJ8. Protein structure suggests a role as the drug-binding, channel-modulating subunit of the extra-pancreatic KATP channels, which are thought to operate in cardiac, skeletal, and vascular and non-vascular smooth muscle.
The ABCC9 gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily, whose proteins transport various molecules across extra- and intracellular membranes. It belongs to the ABCC family, in the MRP subfamily, a group associated with multidrug resistance, and to the conjugate transporter (TC 3.A.1.208) subfamily. HGNC also places it in the group of ATP-sensitive potassium channel subunits. Alternative splicing of the ABCC9 gene results in multiple transcript variants. The protein is a membrane protein with no assigned EC number.
The gene was previously named ATP-binding cassette, sub-family C (CFTR/MRP), member 9, and the symbol SUR2 reflects its role as a sulfonylurea receptor. Mutations in ABCC9 are associated with dilated cardiomyopathy type 1O (CMD1O), which links the channel subunit to heart muscle disease. The related ABCC8 gene is a close relative within the same family and is relevant for comparison in KATP channel studies.
ABCC9 contributes to cardiac-type KATP channels, making it a focus for studies of channel regulation and activation in heart muscle.
Mutations in ABCC9 are associated with cardiomyopathy, dilated type 1O, supporting genetic and mechanistic work on inherited heart disease.
ABCC9 is thought to form KATP channels in vascular and non-vascular smooth muscle, relevant to studies of muscle excitability.
As a drug-binding, channel-modulating subunit, ABCC9 is useful for investigating sulfonylurea-sensitive potassium channel behaviour.
ABCC9 is a subunit of ATP-sensitive potassium channels. With KCNJ11, which forms the pore, it makes cardiac and smooth muscle-type KATP channels and is required for their activation and regulation. It can also form a sulfonylurea-sensitive, ATP-insensitive channel with KCNJ8.
ABCC9 is also known as SUR2 and CMD1O, and was formerly named ATP-binding cassette, sub-family C (CFTR/MRP), member 9. Alternative splicing produces multiple transcript variants. The UniProt accession is O60706.
Orthologs are annotated in mouse and rat, both named Abcc9, so check the datasheet of any product for its validated reactivity. In humans, mutations in ABCC9 are associated with dilated cardiomyopathy type 1O.
Other ABCC family transporters and KATP channel-associated proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60706; product specifications from Assay Genie datasheets.