VGLL3
VGLL3 (vestigial like family member 3, also known as VGL-3) is a nuclear transcription cofactor of the vestigial family. UniProt annotates it as a possible specific coactivator for the mammalian TEF transcription factors. Browse Assay Genie's current range of VGLL3 research reagents below, or read on for the biology behind the target.
VGLL3 is a transcription cofactor. According to UniProt, it may act as a specific coactivator for the mammalian TEFs, the transcription factors that a cofactor of this kind would partner with to influence gene expression. The NCBI Gene summary, which is based on predictions from the Alliance of Genome Resources, describes the gene as involved in the regulation of transcription by RNA polymerase II and as active in the nucleus. This fits the nuclear localisation recorded in UniProt.
The VGLL3 gene encodes the protein UniProt names transcription cofactor vestigial-like protein 3. It belongs to the vestigial family, which HGNC lists as the vestigial like family. The mouse ortholog is Vgll3, which allows the protein to be studied in murine systems. The source data give no tissue expression pattern for VGLL3, so none is described here.
The gene's naming reflects its origin in comparative biology. Its previous HGNC names, vestigial like 3 (Drosophila) and vestigial-like family member 3, refer to the Drosophila vestigial gene that defines the family. The alias VGL-3 is also in use. Because the coactivator role is annotated as possible rather than established, VGLL3 is of interest to researchers working on how vestigial-like proteins shape TEF-dependent transcription.
VGLL3 is predicted to take part in regulation of transcription by RNA polymerase II, making it relevant to studies of cofactor-driven gene control.
UniProt proposes VGLL3 as a specific coactivator for mammalian TEFs, a basis for investigating TEF-cofactor partnerships.
As a member of the vestigial family, VGLL3 is used in comparative work on how related cofactors function.
VGLL3 is annotated as a nuclear protein, so it is relevant to research on nuclear localisation and activity of cofactors.
UniProt states that VGLL3 may act as a specific coactivator for the mammalian TEFs. NCBI Gene predicts involvement in regulation of transcription by RNA polymerase II, with activity in the nucleus. Both descriptions point to a role as a nuclear transcription cofactor.
The HGNC name is vestigial like family member 3, and UniProt calls the protein transcription cofactor vestigial-like protein 3. The alias is VGL-3. Earlier names were vestigial like 3 (Drosophila) and vestigial-like family member 3.
A mouse ortholog, Vgll3, is listed. The family name derives from the Drosophila vestigial gene, which gave the vestigial like family its name. Check the datasheet of any product for its validated reactivity.
Other vestigial like family members and TEF transcription factors that relate to VGLL3 function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt A8MV65; product specifications from Assay Genie datasheets.