MEC
MEC, also known as C-C motif chemokine ligand 28 (CCL28, SCYA28, CCK1), is a secreted CC chemokine with chemotactic activity for resting CD4 and CD8 T cells and eosinophils. It signals through the receptors CCR3 and CCR10. Browse Assay Genie's current range of MEC research reagents below, or read on for the biology behind the target.
MEC is a chemotactic cytokine that attracts resting CD4 and CD8 T cells and eosinophils. It binds the chemokine receptors CCR3 and CCR10 and induces calcium mobilisation in a dose-dependent manner, a hallmark of chemokine receptor activation. The protein is secreted and belongs to the intercrine beta (chemokine CC) family.
The CCL28 gene belongs to the subfamily of small cytokine CC genes. Cytokines are secreted proteins involved in immunoregulatory and inflammatory processes, and CC cytokines are characterised by two adjacent cysteines. NCBI describes the gene as antimicrobial, and suggests that this chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been reported for the MEC gene.
HGNC classifies the gene within the chemokine ligands group. Its approved name is C-C motif chemokine ligand 28, previously chemokine (C-C motif) ligand 28, and it has also been listed under the symbols SCYA28, MEC and CCK1. The mouse ortholog is Ccl28. Researchers studying T cell and eosinophil trafficking, mucosal immunity and chemokine receptor signalling use MEC as a defined ligand for CCR3 and CCR10.
MEC binds CCR3 and CCR10 and induces calcium mobilisation, making it a useful ligand for studying receptor activation.
MEC has chemotactic activity for resting CD4 and CD8 T cells, relevant to studies of lymphocyte trafficking.
MEC attracts eosinophils and acts through CCR3, linking it to research on eosinophil recruitment.
MEC may contribute to the physiology of extracutaneous epithelial tissues, including diverse mucosal organs.
MEC is a secreted CC chemokine with chemotactic activity for resting CD4 and CD8 T cells and eosinophils. It binds CCR3 and CCR10 and induces calcium mobilisation in a dose-dependent manner. It may also play a role in mucosal and other epithelial tissues.
MEC is the product of the CCL28 gene, approved by HGNC as C-C motif chemokine ligand 28. Other names and symbols include SCYA28, MEC and CCK1, and the earlier name chemokine (C-C motif) ligand 28. Multiple transcript variants encode two isoforms.
A mouse ortholog, Ccl28, has been identified for human MEC. NCBI describes the gene as part of the small cytokine CC subfamily, and the protein belongs to the intercrine beta family. Check the datasheet of any product for its validated reactivity.
Other CC chemokine ligands and the receptors CCR3 and CCR10 involved in T cell and eosinophil chemotaxis.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NRJ3; product specifications from Assay Genie datasheets.