CD303
CD303 (C-type lectin domain family 4 member C, also known as CLEC4C, BDCA2, HECL, DLEC, CLECSF7 and CLECSF11) is a lectin-type cell surface receptor of dendritic cells. It may capture antigen and may restrain interferon-alpha/beta induction in plasmacytoid dendritic cells. Browse Assay Genie's current range of CD303 research reagents below, or read on for the biology behind the target.
CD303 is a lectin-type cell surface receptor that may play a role in antigen capturing by dendritic cells. It specifically recognises non-sialylated, galactose-terminated biantennary glycans carrying the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man, and it also binds serum IgG. Once ligand is bound, the receptor efficiently targets it into antigen-processing and peptide-loading compartments for presentation to T-cells.
Beyond antigen uptake, CD303 may mediate potent inhibition of the induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. It may also act as a signalling receptor, activating protein-tyrosine kinases and mobilising intracellular calcium. The CD303 protein is found at the cell membrane, consistent with its role as a surface receptor.
The CLEC4C gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, including cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein is a type 2 transmembrane protein, and two transcript variants encoding distinct isoforms have been identified. HGNC places the gene in the CD molecules, C-type lectin domain containing and Dectin 2 cluster groups. Previous names include C-type lectin superfamily member 7, reflected in the aliases CLECSF7 and CLECSF11, alongside BDCA2, HECL and DLEC.
CD303 is a lectin receptor that may be involved in antigen capture by dendritic cells, making it relevant to studies of dendritic cell function.
The receptor efficiently targets bound ligand into antigen-processing and peptide-loading compartments for presentation to T-cells.
CD303 may mediate potent inhibition of IFN-alpha/beta induction in plasmacytoid dendritic cells, a focus for innate immune signalling research.
It recognises non-sialylated galactose-terminated biantennary glycans, binds serum IgG and may activate protein-tyrosine kinases and calcium mobilisation.
CD303 is a lectin-type cell surface receptor that may capture antigen on dendritic cells and direct it into antigen-processing compartments for presentation to T-cells. It may also inhibit IFN-alpha/beta induction in plasmacytoid dendritic cells and may signal through protein-tyrosine kinases and intracellular calcium.
CD303 is encoded by CLEC4C, and aliases include BDCA2, HECL, DLEC, CLECSF7 and CLECSF11. The full name is C-type lectin domain family 4 member C. Two transcript variants encoding distinct isoforms have been reported for the gene, so check which isoform a study addresses.
CD303 belongs to the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, whose members share a common protein fold. It is a type 2 transmembrane protein and is grouped by HGNC with CD molecules and the Dectin 2 cluster of C-type lectin domain containing genes.
Other C-type lectin domain family members and dendritic cell receptors with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WTT0; product specifications from Assay Genie datasheets.