IL-17B
IL-17B (interleukin 17B, also known as ZCYTO7, NIRF and IL-20) is a secreted, T cell-derived cytokine of the IL-17 family. It shares sequence similarity with IL-17A and stimulates the release of TNF alpha and IL-1 beta from monocytic cells. Browse Assay Genie's current range of IL-17B research reagents below, or read on for the biology behind the target.
IL-17B is a secreted cytokine that belongs to the IL-17 family. Its best-characterised activity is pro-inflammatory: it stimulates the release of tumour necrosis factor alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) from the monocytic cell line THP-1. This places IL-17B among the cytokines that can influence the output of monocyte-lineage cells, and it is the reason the protein is often studied alongside TNF alpha and IL-1 beta signalling.
The IL17B gene encodes a T cell-derived cytokine that shares sequence similarity with IL-17A, the founding member of the family. The HGNC places the gene in the interleukins group, within the interleukin 17 family. According to the NCBI Gene summary, alternative splicing of the gene results in multiple splice variants. Immunohistochemical analysis of several nerve tissues indicated that the cytokine is primarily localised to neuronal cell bodies, an observation that sets it apart from cytokines usually described only in immune compartments. The mouse ortholog is designated Il17b.
IL-17B has been known under several names. Alongside the approved symbol IL17B, the literature and databases use ZCYTO7, NIRF, MGC138900 and MGC138901, and IL-20 also appears as an alias. That last alias can cause confusion, because IL-20 is also the name of a separate cytokine, so it is worth checking gene identifiers when searching the literature or selecting reagents for the IL-17B protein. The UniProt entry for the human protein is Q9UHF5, and the NCBI Gene record is 27190.
IL-17B is a secreted, T cell-derived member of the IL-17 family, making it a useful subject for comparing how related cytokines differ in function.
IL-17B stimulates release of TNF alpha and IL-1 beta from the monocytic THP-1 cell line, supporting studies of cytokine induction.
Immunohistochemistry has localised IL-17B primarily to neuronal cell bodies in several nerve tissues, prompting interest in its role outside classical immune cells.
IL-17B shares sequence similarity with IL-17A, so it features in work that contrasts the properties of the wider IL-17 cytokine family.
IL-17B is a secreted cytokine of the IL-17 family. The annotated function is stimulation of TNF alpha and IL-1 beta release from the monocytic cell line THP-1. It is T cell-derived, and in nerve tissue it has been found mainly in neuronal cell bodies.
IL-17B is also called ZCYTO7, NIRF, MGC138900 and MGC138901, and IL-20 is listed as an alias. The HGNC symbol is IL17B. NCBI Gene reports that alternative splicing gives multiple splice variants, so check which variant a product targets.
A mouse ortholog, Il17b, is recorded for the human gene. The protein belongs to the IL-17 family, which it shares with IL-17A, with which it has sequence similarity. Check the datasheet of any product for its validated reactivity.
Other IL-17 family members and related interleukins, including cytokines induced by IL-17B signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UHF5; product specifications from Assay Genie datasheets.