GSTO1
GSTO1 (glutathione S-transferase omega 1, also known as GSTTLp28 and P28) is a cytosolic omega class glutathione S-transferase. It has glutathione-dependent thiol transferase and dehydroascorbate reductase activities and takes part in the biotransformation of inorganic arsenic. Browse Assay Genie's current range of GSTO1 research reagents below, or read on for the biology behind the target.
GSTO1 exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. It also has S-(phenacyl)glutathione reductase activity, in addition to classical glutathione S-transferase activity. The enzyme participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. As a glutathione S-transferase, it belongs to the wider group of enzymes involved in the metabolism of xenobiotics and carcinogens.
The human GSTO1 gene encodes a 241-amino-acid protein that belongs to the GST superfamily, Omega family. HGNC places it among the soluble glutathione S-transferases and the oxidoreductases. The protein acts as a homodimer and is found in the cytoplasm, specifically the cytosol. Three transcript variants encoding different isoforms have been reported for this gene. Mouse and rat each have a Gsto1 ortholog, which is relevant when planning comparative work.
The symbols GSTTLp28 and P28 are alternative names for the same gene product. Because GSTO1 links glutathione chemistry with arsenic handling and ascorbate recycling through dehydroascorbate reduction, it is a useful subject for studies of detoxification and redox biochemistry. Researchers working with a GSTO1 antibody, GSTO1 ELISA kit or recombinant GSTO1 protein typically do so to measure or manipulate these activities in cell and tissue systems.
GSTs are involved in the metabolism of xenobiotics and carcinogens, making GSTO1 a relevant enzyme for detoxification studies.
GSTO1 participates in inorganic arsenic biotransformation and reduces monomethylarsonic acid and dimethylarsonic acid.
Its dehydroascorbate reductase and glutathione-dependent thiol transferase activities place GSTO1 in glutathione-linked redox research.
GSTO1 also shows S-(phenacyl)glutathione reductase and glutathione S-transferase activity, useful for comparing omega class catalytic behaviour.
GSTO1 is a glutathione-dependent enzyme with thiol transferase, dehydroascorbate reductase, S-(phenacyl)glutathione reductase and glutathione S-transferase activities. It participates in the biotransformation of inorganic arsenic, reducing monomethylarsonic acid and dimethylarsonic acid. It acts as a homodimer in the cytosol.
GSTO1 is also called GSTTLp28 and P28, and its full name is glutathione S-transferase omega 1. Three transcript variants encoding different isoforms have been found for the gene. Check the datasheet of any product for the isoform or region it targets.
Yes. Mouse and rat both carry a Gsto1 ortholog of the human gene. GSTO1 belongs to the Omega family of the GST superfamily. Check the datasheet of any product for its validated reactivity before using it in another species.
Other glutathione S-transferases and detoxification enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P78417; product specifications from Assay Genie datasheets.