ENTPD2
ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2) is the type 2 member of the ecto-nucleoside triphosphate diphosphohydrolase family, an integral membrane ecto-ATPase also known as NTPDase-2 and CD39L1. It belongs to the GDA1/CD39 NTPase family. Browse Assay Genie's current range of ENTPD2 research reagents below, or read on for the biology behind the target.
ENTPD2 is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are ecto-nucleosidases that hydrolyse 5'-triphosphates, and the ENTPD2 protein is described as an ecto-ATPase. It is an integral membrane protein, and UniProt lists its subcellular locations as the cell membrane and the endoplasmic reticulum membrane. Its enzyme classification is EC 3.6.1.5.
The UniProt function annotation for this entry reads simply "catalytically inactive". This sits alongside the NCBI Gene description of the protein as an ecto-ATPase, so researchers studying nucleotide hydrolysis should keep in mind which form of the protein is under investigation. The human ENTPD2 gene undergoes alternative splicing, which results in multiple transcript variants.
The protein is a member of the GDA1/CD39 NTPase family. Its alternative name CD39L1 reflects this relationship, and NTPDase-2 is the name used for the type 2 enzyme within the E-NTPDase nomenclature. HGNC places the gene in the ectonucleoside triphosphate diphosphohydrolase family. Orthologues are annotated in mouse and rat, both named Entpd2, which allows the gene and protein to be examined in common rodent systems. ENTPD2 sits alongside other family members such as ENTPD5 and ENTPD7, and comparing them helps place its properties in the wider context of the family.
ENTPD2 is an ecto-nucleosidase that hydrolyses 5'-triphosphates, making it a subject of study for extracellular nucleotide breakdown.
As an integral membrane protein found at the cell membrane and endoplasmic reticulum membrane, ENTPD2 is relevant to work on membrane enzyme localisation.
As the type 2 E-NTPDase and a GDA1/CD39 NTPase family member, ENTPD2 is used as a reference point when comparing family enzymes.
Alternative splicing of the ENTPD2 gene yields multiple transcript variants, which makes it of interest for studies of isoform-level expression.
ENTPD2 is the type 2 enzyme of the E-NTPDase family of ecto-nucleosidases, which hydrolyse 5'-triphosphates. NCBI Gene describes it as an integral membrane ecto-ATPase. The UniProt function annotation, however, records it as catalytically inactive, so the form under study matters.
ENTPD2 is also called NTPDase-2 and CD39L1, and its full name is ectonucleoside triphosphate diphosphohydrolase 2. The gene is annotated with multiple transcript variants arising from alternative splicing. It is classed in the GDA1/CD39 NTPase family and carries the enzyme number EC 3.6.1.5.
Yes. Orthologues are annotated in both mouse and rat, and each is named Entpd2. This allows the gene and protein to be studied in rodent systems; check the datasheet of any product for its validated reactivity.
Other ectonucleoside triphosphate diphosphohydrolase family members and related nucleotide-metabolising enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y5L3; product specifications from Assay Genie datasheets.