GSTA5
GSTA5 (glutathione S-transferase alpha 5) is a member of the alpha class of the glutathione S-transferase superfamily. Like other GSTs, it is annotated as catalysing the conjugation of reduced glutathione to electrophilic compounds. Browse Assay Genie's current range of GSTA5 research reagents below, or read on for the biology behind the target.
GSTA5 belongs to the glutathione S-transferases (GSTs; EC 2.5.1.18), a group of enzymes that catalyse the conjugation of reduced glutathione with a variety of electrophiles. These electrophilic substrates include many known carcinogens and mutagens, which places the GST family at the centre of research into how cells handle reactive and potentially harmful compounds. UniProt places the protein in the cytoplasm, consistent with its classification among the cytosolic GSTs.
The GSTA5 gene encodes glutathione S-transferase A5, also described by HGNC as glutathione S-transferase alpha 5. The protein belongs to the GST superfamily and, within it, to the alpha family. HGNC lists it in the group of soluble glutathione S-transferases. The cytosolic GSTs form a large superfamily whose members are located on different chromosomes, and the alpha genes are one cluster within it. A rat ortholog, Gsta5, is recorded for this gene.
No individual function annotation is supplied for this protein in UniProt, so its catalytic properties are best considered in the context of the wider GST family. For general background on the GST enzymes, the NCBI Gene summary points readers to GSTA1, the reference entry for the alpha family. Comparing GSTA5 with GSTA1 and the other alpha members is a practical way to place any GSTA5 antibody, GSTA5 ELISA kit or GSTA5 protein experiment in context.
GSTs catalyse the conjugation of reduced glutathione to electrophiles, so GSTA5 is relevant to studies of this core conjugation reaction.
The GST family acts on electrophiles that include many known carcinogens and mutagens, linking GSTA5 to research on chemical exposure.
GSTA5 sits in the alpha family alongside GSTA1 to GSTA4, allowing comparative studies of paralogous cytosolic enzymes.
Cytosolic GSTs form a large superfamily with members on different chromosomes, making GSTA5 useful for gene family and ortholog studies.
GSTA5 is a glutathione S-transferase (EC 2.5.1.18). The GST enzymes catalyse the conjugation of reduced glutathione to a variety of electrophiles, including many known carcinogens and mutagens. UniProt places GSTA5 in the cytoplasm, and no further specific function is annotated for this protein.
The approved HGNC name is glutathione S-transferase alpha 5, and the UniProt protein name is glutathione S-transferase A5. No alternative aliases or previous symbols are recorded. HGNC places it in the soluble glutathione S-transferases gene group.
A rat ortholog, Gsta5, is recorded for this gene, while no mouse ortholog is listed in the data. GSTA5 belongs to the alpha family of the GST superfamily, alongside GSTA1 to GSTA4. Check the datasheet of any product for its validated reactivity.
Other alpha-class glutathione S-transferases and related detoxification enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q7RTV2; product specifications from Assay Genie datasheets.