DNHD1
DNHD1 (dynein heavy chain domain 1) is a member of the dynein heavy chain family that is essential for the normal assembly and function of sperm flagella axonemes. It is also known as DHCD1, C11orf47, DNHD1L and CCDC35. Browse Assay Genie's current range of DNHD1 research reagents below, or read on for the biology behind the target.
DNHD1 is essential for the normal assembly and function of sperm flagella axonemes. The axoneme is the microtubule-based core of the flagellum, and dynein-family proteins are associated with the motor activity that drives it. Consistent with this, the NCBI Gene summary describes DNHD1 as predicted to enable minus-end-directed microtubule motor activity, as well as dynein intermediate chain binding and dynein light intermediate chain binding. It is involved in sperm flagellum assembly.
The DNHD1 protein belongs to the dynein heavy chain family and is annotated to the cell projection compartment, specifically the cilium and flagellum. In the sperm it is located in the sperm annulus and the sperm midpiece. The human gene lies on chromosome 11 and has a mouse ortholog, Dnhd1, which allows the protein to be studied in a model organism.
DNHD1 has been renamed several times. Earlier names include chromosome 11 open reading frame 47 (C11orf47), dynein heavy chain domain 1-like (DNHD1L) and coiled-coil domain containing 35 (CCDC35). Variation in the DNHD1 gene is implicated in spermatogenic failure 65, which links the protein to male fertility and to the structure of the sperm tail.
Researchers working on DNHD1 antibody or DNHD1 ELISA kit based approaches should note these alternative names when searching the literature and databases.
DNHD1 is essential for the assembly and function of sperm flagella axonemes, making it a useful target for studying how the sperm tail is built.
The DNHD1 gene is implicated in spermatogenic failure 65, so the protein is relevant to studies of genetic causes of impaired spermatogenesis.
As a dynein heavy chain family member predicted to bind dynein intermediate and light intermediate chains, DNHD1 informs work on minus-end-directed microtubule motors.
DNHD1 is located in the sperm annulus and midpiece, supporting studies of the subcellular organisation of the mature sperm.
DNHD1 is essential for the normal assembly and function of sperm flagella axonemes. It is predicted to bind dynein intermediate and light intermediate chains and to have minus-end-directed microtubule motor activity, and it is involved in sperm flagellum assembly.
DNHD1 is also called DHCD1, DNHD1L, C11orf47 and CCDC35, with further aliases FLJ32752, FLJ46184, FLJ35709 and DKFZp686J0796. Previous names include chromosome 11 open reading frame 47, dynein heavy chain domain 1-like and coiled-coil domain containing 35.
DNHD1 is implicated in spermatogenic failure 65. A mouse ortholog, Dnhd1, exists, so the protein can be studied in mouse models. Check the datasheet of any product for its validated reactivity.
Other dynein family members, axonemal proteins and sperm flagellum markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96M86; product specifications from Assay Genie datasheets.