TP73
TP73 (tumour protein p73, also known as P73) is a member of the p53 family of transcription factors that takes part in cellular responses to stress and in development. It contributes to the apoptotic response to DNA damage and is a candidate tumour suppressor. Browse Assay Genie's current range of TP73 research reagents below, or read on for the biology behind the target.
TP73 participates in the apoptotic response to DNA damage. Its activity depends on which isoform is produced. Isoforms that contain the transactivation domain are pro-apoptotic. Isoforms that lack this domain are anti-apoptotic and block the function of p53 and of transactivating p73 isoforms. This balance between opposing isoforms makes TP73 expression a subject of close study in cell-death research. The protein is also described as an activator of FOXJ1 expression and as an essential factor for the positive regulation of lung ciliated cell differentiation.
The TP73 gene encodes a member of the p53 family of transcription factors, which are involved in cellular responses to stress and in development. The protein is found in the nucleus and the cytoplasm. Many transcript variants arise through alternative splicing and the use of alternate promoters, although the biological validity and full-length nature of some variants have not been determined. Researchers working with the p73 protein therefore need to consider which isoforms are relevant to their system.
The gene maps to a region of chromosome 1p36 that is frequently deleted in neuroblastoma and other tumours, and which is thought to contain multiple tumour suppressor genes. TP73 is monoallelically expressed, likely from the maternal allele, which supports its status as a candidate gene for neuroblastoma. UniProt notes that it may be a tumour suppressor protein. The mouse ortholog is Tp73.
TP73 participates in the apoptotic response to DNA damage, with pro- and anti-apoptotic isoforms shaping cell fate.
TP73 may act as a tumour suppressor and lies in a 1p36 region frequently deleted in neuroblastoma and other tumours.
Anti-apoptotic isoforms block p53 and transactivating p73 isoforms, making TP73 central to studies of p53 family cross-talk.
TP73 activates FOXJ1 expression and is essential for positive regulation of lung ciliated cell differentiation.
TP73 is a p53 family transcription factor that participates in the apoptotic response to DNA damage. Isoforms with the transactivation domain are pro-apoptotic, while those lacking it are anti-apoptotic. It also activates FOXJ1 expression and is essential for lung ciliated cell differentiation.
Many transcript variants result from alternative splicing and the use of alternate promoters. Their functions differ, since isoforms with or without the transactivation domain have opposing effects on apoptosis. The validity and full-length nature of some variants remain undetermined, so check the datasheet of any product for its validated reactivity.
TP73 maps to chromosome 1p36, a region frequently deleted in neuroblastoma and other tumours. Its monoallelic expression, likely from the maternal allele, supports it as a candidate gene for neuroblastoma, and UniProt notes it may be a tumour suppressor. Mouse Tp73 is the corresponding ortholog.
Other p53 family members and p53-related proteins that sit alongside TP73 in stress-response and cell-death research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15350; product specifications from Assay Genie datasheets.