SP1
SP1 (Sp1 transcription factor) is a C2H2-type zinc finger protein that binds GC-rich promoter motifs and can either activate or repress transcription. It regulates genes involved in cell growth, apoptosis, differentiation and immune responses. Browse Assay Genie's current range of SP1 research reagents below, or read on for the biology behind the target.
SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. It binds with high affinity to GC-rich motifs and regulates a large number of genes involved in cell growth, apoptosis, differentiation and immune responses. It also binds the PDGFR-alpha G-box promoter, may help modulate the cellular response to DNA damage, and has been implicated in chromatin remodelling.
Specific roles have been described for SP1 at individual genes. It plays an essential role in regulating FE65 expression, and in complex with ATF7IP it maintains telomerase activity in cancer cells by inducing TERT and TERC expression. It positively regulates transcription of the core clock component BMAL1, contributes to recruitment of SMARCA4/BRG1 to the c-FOS promoter, and helps protect cells against oxidative stress after brain injury by regulating RNF112 expression.
The SP1 gene encodes a 785-residue protein of the Sp1 C2H2-type zinc-finger family, grouped by HGNC with the Sp transcription factors. Its activity is strongly shaped by post-translational modifications, including phosphorylation, sumoylation, proteolytic cleavage, glycosylation and acetylation. Three transcript variants encoding different isoforms are known; isoform 3 is a stronger transcriptional activator than isoform 1. Mouse and rat both have an Sp1 ortholog. Researchers studying the SP1 gene or protein often examine modification state alongside expression.
SP1 binds GC-rich promoter motifs and can activate or repress transcription, making it a central factor for studying promoter control.
With ATF7IP, SP1 induces TERT and TERC expression to maintain telomerase activity in cancer cells.
SP1 is implicated in chromatin remodelling, supports SMARCA4/BRG1 recruitment to the c-FOS promoter and may modulate DNA damage responses.
SP1 positively regulates BMAL1 transcription and controls RNF112 expression, linking it to clock regulation and oxidative stress protection after brain injury.
SP1 is a zinc finger transcription factor that binds GC-rich motifs in many promoters and can activate or repress transcription. It regulates genes involved in cell growth, apoptosis, differentiation, immune responses, DNA damage response and chromatin remodelling.
The SP1 gene has three transcript variants encoding different isoforms. Isoform 3 is a stronger activator of transcription than isoform 1. HGNC lists the name as Sp1 transcription factor, and UniProt uses Transcription factor Sp1; no other aliases are recorded.
Yes. Both mouse and rat have an Sp1 ortholog, and the protein belongs to the Sp1 C2H2-type zinc-finger family. Check the datasheet of any product for its validated reactivity.
Other Sp family transcription factors and related regulators of gene expression with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P08047; product specifications from Assay Genie datasheets.